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GLASS

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GPCR

Name	Probable G-protein coupled receptor 142
Species	Homo sapiens (Human)
Gene	GPR142
Synonym	AXOR103 G-protein coupled receptor PGR2 GPR142 KIF19
Disease	N/A
Length	462
Amino acid sequence	MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
UniProt	Q7Z601
Protein Data Bank	N/A
GPCR-HGmod model	Q7Z601
3D structure model	This predicted structure model is from GPCR-EXP Q7Z601.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2069161
IUPHAR	132
DrugBank	N/A

Ligand

Name	CHEMBL2409007
Molecular formula	C22H30N8O2
IUPAC name	5-(ethoxymethyl)-N-[(3-methylimidazol-4-yl)methyl]-1-(5-methyl-4-piperidin-1-ylpyrimidin-2-yl)pyrazole-4-carboxamide
Molecular weight	438.536
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	1.1
Synonyms	SCHEMBL2392940 BDBM50437413 compound 33 [Toda et al., 2013] 5-(ethoxymethyl)-n-((1-methyl-1h-imidazol-5-yl)methyl)-1-(5-methyl-4-(piperidin-1-yl)pyrimidin-2-yl)-1h-pyrazole-4-carboxamide 5-(ethoxymethyl)-N-[(3-methylimidazol-4-yl)methyl]-1-(5-methyl-4-piperidin-1-ylpyrimidin-2-yl)pyrazole-4-carboxamide GTPL8791 ATOKVTDUHKZLMB-UHFFFAOYSA-N [ Show all ]
Inchi Key	ATOKVTDUHKZLMB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H30N8O2/c1-4-32-14-19-18(21(31)24-12-17-11-23-15-28(17)3)13-26-30(19)22-25-10-16(2)20(27-22)29-8-6-5-7-9-29/h10-11,13,15H,4-9,12,14H2,1-3H3,(H,24,31)
PubChem CID	60207864
ChEMBL	CHEMBL2409007
IUPHAR	8791
BindingDB	50437413
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	22.0 nM	PMID24900747	BindingDB,IUPHAR,ChEMBL

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