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GPCR

NameC-C chemokine receptor type 3
SpeciesHomo sapiens (Human)
GeneCCR3
SynonymMIP-1alphaRL-2 (mouse)
Eosinophil eotaxin receptor
CKR3
chemokine (C-C motif) receptor 3
CD193
[ Show all ]
DiseaseAllergic asthma
Allergic rhinitis
Asthma
Length355
Amino acid sequenceMTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
UniProtP51677
Protein Data BankN/A
GPCR-HGmod modelP51677
3D structure modelThis predicted structure model is from GPCR-EXP P51677.
BioLiPN/A
Therapeutic Target DatabaseT02752, T85228
ChEMBLCHEMBL3473
IUPHAR60
DrugBankN/A

Ligand

NameCHEMBL361430
Molecular formulaC20H20BrN3S
IUPAC name(10E)-10-[(2-bromophenyl)methylidene]-4-tert-butyl-6-thia-1,8-diazatricyclo[7.3.0.03,7]dodeca-3(7),4,8-trien-2-imine
Molecular weight414.365
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.5
SynonymsSCHEMBL18840819
8-[1-(2-Bromo-phenyl)-meth-(E)-ylidene]-3-tert-butyl-7,8-dihydro-6H-pyrrolo[1,2-a]thieno[2,3-d]pyrimidin-(4Z)-ylideneamine
BDBM50160191
Inchi KeyAUHVLVLVAOKAMR-GOPRIXMCSA-N
Inchi IDInChI=1S/C20H20BrN3S/c1-20(2,3)14-11-25-19-16(14)17(22)24-9-8-13(18(24)23-19)10-12-6-4-5-7-15(12)21/h4-7,10-11,22H,8-9H2,1-3H3/b13-10+,22-17?
PubChem CID44391160
ChEMBLCHEMBL361430
IUPHARN/A
BindingDB50160191
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki1200.0 nMPMID15664834BindingDB,ChEMBL

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