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GPCR

NameNeuropeptide FF receptor 1
SpeciesHomo sapiens (Human)
GeneNPFFR1
SynonymGnIH-R
G protein-coupled receptor 147
OT7T022
NPFF1R1
NPFF1 receptor
[ Show all ]
DiseaseN/A
Length430
Amino acid sequenceMEGEPSQPPNSSWPLSQNGTNTEATPATNLTFSSYYQHTSPVAAMFIVAYALIFLLCMVGNTLVCFIVLKNRHMHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALVTIAVIWALALLIMCPSAVTLTVTREEHHFMVDARNRSYPLYSCWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVMYARIARKLCQAPGPAPGGEEAADPRASRRRARVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSAPQLHLVTVYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRARLCPRPSGSHKEAYSERPGGLLHRRVFVVVRPSDSGLPSESGPSSGAPRPGRLPLRNGRVAHHGLPREGPGCSHLPLTIPAWDI
UniProtQ9GZQ6
Protein Data BankN/A
GPCR-HGmod modelQ9GZQ6
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZQ6.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5951
IUPHAR300
DrugBankN/A

Ligand

Name311309-27-0
Molecular formulaC45H72N14O10
IUPAC name(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-4-amino-2-[[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pentanediamide
Molecular weight969.159
Hydrogen bond acceptor12
Hydrogen bond donor11
XlogP-2.5
SynonymsZINC169289418
Neuropeptide NPVF
BDBM50029188
RFRP 3 (human)
CHEMBL2165920
[ Show all ]
Inchi KeyJFZCLMZUABKABL-GVCDGELBSA-N
Inchi IDInChI=1S/C45H72N14O10/c1-24(2)21-31(57-40(65)30(23-35(47)61)56-42(67)33-15-10-20-59(33)44(69)36(48)25(3)4)43(68)58-19-9-14-32(58)41(66)54-28(16-17-34(46)60)39(64)53-27(13-8-18-52-45(50)51)38(63)55-29(37(49)62)22-26-11-6-5-7-12-26/h5-7,11-12,24-25,27-33,36H,8-10,13-23,48H2,1-4H3,(H2,46,60)(H2,47,61)(H2,49,62)(H,53,64)(H,54,66)(H,55,63)(H,56,67)(H,57,65)(H4,50,51,52)/t27-,28-,29-,30-,31-,32-,33-,36-/m0/s1
PubChem CID71451611
ChEMBLCHEMBL2165920
IUPHARN/A
BindingDB50029188, 86143
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC501.7 nMPMID22708927BindingDB,ChEMBL
EC504.9 nMPMID22708927ChEMBL
EC507.7 nMPMID22708927ChEMBL
EC509.9 nMPMID22708927ChEMBL
EC5016.0 nMPMID22708927ChEMBL
EC5099.0 nMPMID22708927ChEMBL
EC50314.0 nMPMID22708927ChEMBL
EC507876.0 nMPMID22708927ChEMBL
Emax66.0 %PMID22708927ChEMBL
Emax86.0 %PMID22708927ChEMBL
Emax87.0 %PMID22708927ChEMBL
Emax90.0 %PMID22708927ChEMBL
Emax101.0 %PMID22708927ChEMBL
Emax105.0 %PMID22708927ChEMBL
Ki3.66 nMPMID25268943ChEMBL
Ki3.7 nMPMID25268943BindingDB
Ratio EC502.0 -PMID22708927ChEMBL
Ratio EC505.0 -PMID22708927ChEMBL
Ratio EC506.0 -PMID22708927ChEMBL
Ratio EC509.0 -PMID22708927ChEMBL
Ratio EC5058.0 -PMID22708927ChEMBL
Ratio EC50184.0 -PMID22708927ChEMBL
Ratio EC504632.0 -PMID22708927ChEMBL

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