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GPCR

NameC-C chemokine receptor type 2
SpeciesHomo sapiens (Human)
GeneCCR2
SynonymMCP-1-R
Monocyte chemoattractant protein 1 receptor
CKR2
MCP-1 receptor
chemokine receptor CCR2
[ Show all ]
DiseaseChronic obstructive pulmonary disease
Neuropathic pain
Multiple scierosis
Metastatic cancer; Multiple scierosis
Inflammatory disease
[ Show all ]
Length374
Amino acid sequenceMLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
UniProtP41597
Protein Data Bank6gpx, 6gps
GPCR-HGmod modelP41597
3D structure modelThis structure is from PDB ID 6gpx.
BioLiPBL0437328,BL0437329, BL0437327, BL0437326, BL0437325
Therapeutic Target DatabaseT89988
ChEMBLCHEMBL4015
IUPHAR59
DrugBankN/A

Ligand

NameCHEMBL133748
Molecular formulaC17H10Cl2F3NO2
IUPAC name1-[(3,4-dichlorophenyl)methyl]-7-(trifluoromethyl)indole-2-carboxylic acid
Molecular weight388.167
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP5.6
SynonymsSCHEMBL6308114
1-(3,4-Dichloro-benzyl)-7-trifluoromethyl-1H-indole-2-carboxylic acid
BDBM50138368
Inchi KeyAVCNZVYXTKACMS-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H10Cl2F3NO2/c18-12-5-4-9(6-13(12)19)8-23-14(16(24)25)7-10-2-1-3-11(15(10)23)17(20,21)22/h1-7H,8H2,(H,24,25)
PubChem CID22310953
ChEMBLCHEMBL133748
IUPHARN/A
BindingDB50138368
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC501270.0 nMPMID14698169BindingDB,ChEMBL

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