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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Vasopressin V2 receptor
Species	Rattus norvegicus (Rat)
Gene	Avpr2
Synonym	AVPR V2 Antidiuretic hormone receptor ADHR Renal-type arginine vasopressin receptor V2 receptor V2R DIR3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	371
Amino acid sequence	MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
UniProt	Q00788
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3766
IUPHAR	368
DrugBank	N/A

Ligand

Name	CHEMBL2373370
Molecular formula	C52H81N13O10
IUPAC name	(2S)-N-[(2S)-6-amino-1-[(2R)-2-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-(3,3-dimethylbutanoylamino)-3-(4-ethoxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]butanediamide
Molecular weight	1048.3
Hydrogen bond acceptor	12
Hydrogen bond donor	11
XlogP	0.9
Synonyms	N/A
Inchi Key	AXVAHJKXGRNAHY-YGSCYDSESA-N
Inchi ID	InChI=1S/C52H81N13O10/c1-7-75-34-22-20-33(21-23-34)28-37(59-42(67)30-52(4,5)6)45(69)62-38(27-32-15-9-8-10-16-32)47(71)64-43(31(2)3)49(73)63-39(29-41(54)66)46(70)61-36(17-11-12-24-53)50(74)65-26-14-19-40(65)48(72)60-35(44(55)68)18-13-25-58-51(56)57/h8-10,15-16,20-23,31,35-40,43H,7,11-14,17-19,24-30,53H2,1-6H3,(H2,54,66)(H2,55,68)(H,59,67)(H,60,72)(H,61,70)(H,62,69)(H,63,73)(H,64,71)(H4,56,57,58)/t35-,36-,37+,38-,39-,40+,43-/m0/s1
PubChem CID	44335447
ChEMBL	CHEMBL2373370
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Effective dose	<7.0 nM kg-1	PMID2231609	ChEMBL
Ratio	41.0 -	PMID2231609	ChEMBL

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