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Name | P2Y purinoceptor 14 |
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Species | Mus musculus (Mouse) |
Gene | P2ry14 |
Synonym | G protein-coupled receptor 105 G-protein coupled receptor 105 GPR105 G protein coupled receptor for UDP-glucose P2Y purinoceptor 14 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 338 |
Amino acid sequence | MNNSTTTDPPNQPCSWNTLITKQIIPVLYGMVFITGLLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLGDSGLGPWQVNVFVCRVSAVIFYVNMYVSIVFFGLISFDRYYKIVKPLLTSIVQSVNYSKLLSVLVWMLMLLLAVPNIILTNQGVKEVTKIQCMELKNELGRKWHKASNYIFVSIFWVVFLLLIVFYTAITRKIFKSHLKSRKNSTSVKRKSSRNIFSIVLVFVVCFVPYHIARIPYTKSQTEGHYSCRTKETLLYAKEFTLLLSAANVCLDPIIYFFLCQPFREVLNKKLHMSLKVQNDLEVSKTKRENAIHESTDTL |
UniProt | Q9ESG6 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1770046 |
IUPHAR | 330 |
DrugBank | N/A |
Name | CHEMBL1771231 |
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Molecular formula | C26H22ClN5O |
IUPAC name | N-(2-chlorophenyl)-4-(2-methylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide |
Molecular weight | 455.946 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 4.2 |
Synonyms | N/A |
Inchi Key | KNDVFDQFSOHVOI-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C26H22ClN5O/c1-17-7-2-3-9-19(17)24-20-16-32(26(33)30-23-11-5-4-10-21(23)27)14-12-22(20)29-25(31-24)18-8-6-13-28-15-18/h2-11,13,15H,12,14,16H2,1H3,(H,30,33) |
PubChem CID | 54580546 |
ChEMBL | CHEMBL1771231 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Inhibition | >50.0 % | PMID21507642 | ChEMBL |
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