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Name | Gonadotropin-releasing hormone receptor |
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Species | Homo sapiens (Human) |
Gene | GNRHR |
Synonym | LHRHR GnRH I receptor Type I GnRHR gnRH receptor GnRH-R [ Show all ] |
Disease | Uterine leiomyoma Hypothalamic hypogonadism Ovulation Prostate cancer Prostate disease [ Show all ] |
Length | 328 |
Amino acid sequence | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL |
UniProt | P30968 |
Protein Data Bank | N/A |
GPCR-HGmod model | P30968 |
3D structure model | This predicted structure model is from GPCR-EXP P30968. |
BioLiP | N/A |
Therapeutic Target Database | T12475 |
ChEMBL | CHEMBL1855 |
IUPHAR | 256 |
DrugBank | BE0000203 |
Name | CHEMBL322283 |
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Molecular formula | C22H23F2N3O3 |
IUPAC name | 3-[(2S)-2-aminopropyl]-1-[(2,6-difluorophenyl)methyl]-5-(3-methoxyphenyl)-6-methylpyrimidine-2,4-dione |
Molecular weight | 415.441 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 1 |
XlogP | 2.6 |
Synonyms | 1-(2,6-Difluorobenzyl)-3-[(S)-2-aminopropyl]-5-(3-methoxyphenyl)-6-methyluracil BDBM50132741 3-((S)-2-Amino-propyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione |
Inchi Key | AYPFBVKPMHZLON-ZDUSSCGKSA-N |
Inchi ID | InChI=1S/C22H23F2N3O3/c1-13(25)11-27-21(28)20(15-6-4-7-16(10-15)30-3)14(2)26(22(27)29)12-17-18(23)8-5-9-19(17)24/h4-10,13H,11-12,25H2,1-3H3/t13-/m0/s1 |
PubChem CID | 44340649 |
ChEMBL | CHEMBL322283 |
IUPHAR | N/A |
BindingDB | 50132741 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 18000.0 nM | PMID12951116 | BindingDB,ChEMBL |
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