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Name | P2Y purinoceptor 14 |
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Species | Mus musculus (Mouse) |
Gene | P2ry14 |
Synonym | G protein-coupled receptor 105 G-protein coupled receptor 105 GPR105 G protein coupled receptor for UDP-glucose P2Y purinoceptor 14 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 338 |
Amino acid sequence | MNNSTTTDPPNQPCSWNTLITKQIIPVLYGMVFITGLLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLGDSGLGPWQVNVFVCRVSAVIFYVNMYVSIVFFGLISFDRYYKIVKPLLTSIVQSVNYSKLLSVLVWMLMLLLAVPNIILTNQGVKEVTKIQCMELKNELGRKWHKASNYIFVSIFWVVFLLLIVFYTAITRKIFKSHLKSRKNSTSVKRKSSRNIFSIVLVFVVCFVPYHIARIPYTKSQTEGHYSCRTKETLLYAKEFTLLLSAANVCLDPIIYFFLCQPFREVLNKKLHMSLKVQNDLEVSKTKRENAIHESTDTL |
UniProt | Q9ESG6 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1770046 |
IUPHAR | 330 |
DrugBank | N/A |
Name | CHEMBL1771249 |
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Molecular formula | C27H24ClN5O |
IUPAC name | 4-(3-chlorophenyl)-N-(3-ethylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide |
Molecular weight | 469.973 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 4.6 |
Synonyms | BDBM50343114 4-(3-chlorophenyl)-N-(3-ethylphenyl)-2-(pyridin-3-yl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide |
Inchi Key | LGJFKJZACFWJMH-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C27H24ClN5O/c1-2-18-6-3-10-22(14-18)30-27(34)33-13-11-24-23(17-33)25(19-7-4-9-21(28)15-19)32-26(31-24)20-8-5-12-29-16-20/h3-10,12,14-16H,2,11,13,17H2,1H3,(H,30,34) |
PubChem CID | 54585444 |
ChEMBL | CHEMBL1771249 |
IUPHAR | N/A |
BindingDB | 50343114 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 12000.0 nM | PMID21507642 | BindingDB,ChEMBL |
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