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GPCR

NameP2Y purinoceptor 14
SpeciesMus musculus (Mouse)
GeneP2ry14
SynonymG protein-coupled receptor 105
G-protein coupled receptor 105
GPR105
G protein coupled receptor for UDP-glucose
P2Y purinoceptor 14
[ Show all ]
DiseaseN/A for non-human GPCRs
Length338
Amino acid sequenceMNNSTTTDPPNQPCSWNTLITKQIIPVLYGMVFITGLLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLGDSGLGPWQVNVFVCRVSAVIFYVNMYVSIVFFGLISFDRYYKIVKPLLTSIVQSVNYSKLLSVLVWMLMLLLAVPNIILTNQGVKEVTKIQCMELKNELGRKWHKASNYIFVSIFWVVFLLLIVFYTAITRKIFKSHLKSRKNSTSVKRKSSRNIFSIVLVFVVCFVPYHIARIPYTKSQTEGHYSCRTKETLLYAKEFTLLLSAANVCLDPIIYFFLCQPFREVLNKKLHMSLKVQNDLEVSKTKRENAIHESTDTL
UniProtQ9ESG6
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1770046
IUPHAR330
DrugBankN/A

Ligand

NameCHEMBL1771246
Molecular formulaC28H26ClN5O
IUPAC nameN-(3-chloro-5-ethylphenyl)-4-(2-methylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
Molecular weight484.0
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP5.0
SynonymsSCHEMBL13246164
BDBM50343111
N-(3-chloro-5-ethylphenyl)-2-(pyridin-3-yl)-4-o-tolyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
Inchi KeyLRBOERLHXGWTDM-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H26ClN5O/c1-3-19-13-21(29)15-22(14-19)31-28(35)34-12-10-25-24(17-34)26(23-9-5-4-7-18(23)2)33-27(32-25)20-8-6-11-30-16-20/h4-9,11,13-16H,3,10,12,17H2,1-2H3,(H,31,35)
PubChem CID54585443
ChEMBLCHEMBL1771246
IUPHARN/A
BindingDB50343111
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50160.0 nMPMID21507642BindingDB,ChEMBL

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