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GPCR

NameBeta-3 adrenergic receptor
SpeciesHomo sapiens (Human)
GeneADRB3
SynonymADRB
Adrb-3
adrenergic receptor
atypical beta-adrenoceptor
beta 3-AR
[ Show all ]
DiseaseUrinary incontinence
Diabetes
Glaucoma
Hypertension
Irritable bowel syndrome
[ Show all ]
Length408
Amino acid sequenceMAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
UniProtP13945
Protein Data BankN/A
GPCR-HGmod modelP13945
3D structure modelThis predicted structure model is from GPCR-EXP P13945.
BioLiPN/A
Therapeutic Target DatabaseT51408
ChEMBLCHEMBL246
IUPHAR30
DrugBankBE0001012, BE0004872

Ligand

Name5-[4-[4-[[(2R)-2-Hydroxy-2-[3-(methylsulfonylamino)phenyl]ethyl]amino]piperidino]benzyl]-2,4-thiazolidinedione
Molecular formulaC24H30N4O5S2
IUPAC nameN-[3-[(1R)-2-[[1-[4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenyl]piperidin-4-yl]amino]-1-hydroxyethyl]phenyl]methanesulfonamide
Molecular weight518.647
Hydrogen bond acceptor9
Hydrogen bond donor4
XlogP2.1
SynonymsN/A
Inchi KeyBFGUKMAGBVXKJK-HMTLIYDFSA-N
Inchi IDInChI=1S/C24H30N4O5S2/c1-35(32,33)27-19-4-2-3-17(14-19)21(29)15-25-18-9-11-28(12-10-18)20-7-5-16(6-8-20)13-22-23(30)26-24(31)34-22/h2-8,14,18,21-22,25,27,29H,9-13,15H2,1H3,(H,26,30,31)/t21-,22?/m0/s1
PubChem CID44377820
ChEMBLCHEMBL164065
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50<10000.0 nMPMID11277513ChEMBL

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