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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Cannabinoid receptor 1
Species	Rattus norvegicus (Rat)
Gene	Cnr1
Synonym	SKR6R Neuronal cannabinoid receptor Central cannabinoid receptor CB1R CB1 receptor CB1 CB-R Cann7 Cann6 Brain-type cannabinoid receptor THC receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	473
Amino acid sequence	MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
UniProt	P20272
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3571
IUPHAR	56
DrugBank	N/A

Ligand

Name	CHEMBL556686
Molecular formula	C24H24Cl2N4O
IUPAC name	5-(4-cyclopropylphenyl)-1-(2,4-dichlorophenyl)-N-piperidin-1-ylpyrazole-3-carboxamide
Molecular weight	455.383
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	6.4
Synonyms	BDBM50295028 SCHEMBL14155480 5-(4-Cyclopropylphenyl)-1-(2,4-dichlorophenyl)-N-piperidin-1-yl-1-H-pyrazole-3-carboxamide Hydrochloride
Inchi Key	BGVFLXMEMBTJLQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H24Cl2N4O/c25-19-10-11-22(20(26)14-19)30-23(18-8-6-17(7-9-18)16-4-5-16)15-21(27-30)24(31)28-29-12-2-1-3-13-29/h6-11,14-16H,1-5,12-13H2,(H,28,31)
PubChem CID	44190749
ChEMBL	CHEMBL556686
IUPHAR	N/A
BindingDB	50295028
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	16.0 nM	PMID19527048	BindingDB,ChEMBL

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