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GPCR

NamePyroglutamylated RF-amide peptide receptor
SpeciesHomo sapiens (Human)
GeneQRFPR
SynonymQRFP receptor
peptide p518 receptor
Orexigenic neuropeptide QRFP receptor
GPR103
G-protein coupled receptor 103
[ Show all ]
DiseaseN/A
Length431
Amino acid sequenceMQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
UniProtQ96P65
Protein Data BankN/A
GPCR-HGmod modelQ96P65
3D structure modelThis predicted structure model is from GPCR-EXP Q96P65.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5852
IUPHAR333
DrugBankN/A

Ligand

NameCHEMBL1802365
Molecular formulaC43H59N11O7
IUPAC name(2S)-2-[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]hexanamide
Molecular weight842.015
Hydrogen bond acceptor9
Hydrogen bond donor10
XlogP1.3
SynonymsBDBM50347837
Inchi KeyNZQNAWMWYLJVEQ-ZZTWKDBPSA-N
Inchi IDInChI=1S/C43H59N11O7/c1-2-3-20-31(51-41(60)34(24-29-16-9-5-10-17-29)50-37(56)27-49-36(55)26-44)40(59)54-35(25-30-18-11-6-12-19-30)42(61)52-32(21-13-22-48-43(46)47)39(58)53-33(38(45)57)23-28-14-7-4-8-15-28/h4-12,14-19,31-35H,2-3,13,20-27,44H2,1H3,(H2,45,57)(H,49,55)(H,50,56)(H,51,60)(H,52,61)(H,53,58)(H,54,59)(H4,46,47,48)/t31-,32-,33-,34-,35-/m0/s1
PubChem CID53363536
ChEMBLCHEMBL1802365
IUPHARN/A
BindingDB50347837
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50741.0 nMPMID21623631BindingDB,ChEMBL

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