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Name | Gonadotropin-releasing hormone receptor |
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Species | Homo sapiens (Human) |
Gene | GNRHR |
Synonym | LHRHR GnRH I receptor Type I GnRHR gnRH receptor GnRH-R [ Show all ] |
Disease | Uterine leiomyoma Hypothalamic hypogonadism Ovulation Prostate cancer Prostate disease [ Show all ] |
Length | 328 |
Amino acid sequence | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL |
UniProt | P30968 |
Protein Data Bank | N/A |
GPCR-HGmod model | P30968 |
3D structure model | This predicted structure model is from GPCR-EXP P30968. |
BioLiP | N/A |
Therapeutic Target Database | T12475 |
ChEMBL | CHEMBL1855 |
IUPHAR | 256 |
DrugBank | BE0000203 |
Name | CHEMBL342908 |
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Molecular formula | C35H38ClF3N4O5 |
IUPAC name | 7-chloro-N-[4-(dimethylamino)phenyl]-3-(3,5-dimethylphenyl)-2-oxo-4-(2-piperidin-2-ylethoxy)-1H-quinoline-6-carboxamide;2,2,2-trifluoroacetic acid |
Molecular weight | 687.157 |
Hydrogen bond acceptor | 10 |
Hydrogen bond donor | 4 |
XlogP | None |
Synonyms | N/A |
Inchi Key | BNQBPPZAPHYZNI-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C33H37ClN4O3.C2HF3O2/c1-20-15-21(2)17-22(16-20)30-31(41-14-12-23-7-5-6-13-35-23)27-18-26(28(34)19-29(27)37-33(30)40)32(39)36-24-8-10-25(11-9-24)38(3)4;3-2(4,5)1(6)7/h8-11,15-19,23,35H,5-7,12-14H2,1-4H3,(H,36,39)(H,37,40);(H,6,7) |
PubChem CID | 49796681 |
ChEMBL | CHEMBL342908 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 10.9 nM | PMID10743944 | ChEMBL |
IC50 | 360.0 nM | PMID10743944 | ChEMBL |
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