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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	CHEMBL398762
Molecular formula	C20H20N6O3
IUPAC name	2-[[4-(6-aminoquinoxalin-2-yl)piperazine-1-carbonyl]amino]benzoic acid
Molecular weight	392.419
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	1.7
Synonyms	BDBM50227769 SCHEMBL13666065 2-(1-(6-aminoquinoxalin-2-yl)piperazine-4-carboxamido)benzoic acid
Inchi Key	BORJQNRTQNIWGQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H20N6O3/c21-13-5-6-16-17(11-13)22-12-18(23-16)25-7-9-26(10-8-25)20(29)24-15-4-2-1-3-14(15)19(27)28/h1-6,11-12H,7-10,21H2,(H,24,29)(H,27,28)
PubChem CID	16048843
ChEMBL	CHEMBL398762
IUPHAR	N/A
BindingDB	50227769
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	74.0 %	PMID18029181	ChEMBL
EC50	17000.0 nM	PMID18029181	BindingDB,ChEMBL
IC50	6700.0 nM	PMID18029181	BindingDB,ChEMBL

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