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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	C-C chemokine receptor type 3
Species	Homo sapiens (Human)
Gene	CCR3
Synonym	MIP-1alphaRL-2 (mouse) Eosinophil eotaxin receptor CKR3 chemokine (C-C motif) receptor 3 CD193 CCR3 CCR-3 CC-CKR-3 CC CKR3 C-C CKR-3 [ Show all ]
Disease	Allergic asthma Allergic rhinitis Asthma
Length	355
Amino acid sequence	MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
UniProt	P51677
Protein Data Bank	N/A
GPCR-HGmod model	P51677
3D structure model	This predicted structure model is from GPCR-EXP P51677.
BioLiP	N/A
Therapeutic Target Database	T02752, T85228
ChEMBL	CHEMBL3473
IUPHAR	60
DrugBank	N/A

Ligand

Name	CHEMBL33589
Molecular formula	C23H22N2O5
IUPAC name	propan-2-yl (2S)-2-(naphthalene-1-carbonylamino)-3-(4-nitrophenyl)propanoate
Molecular weight	406.438
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	5.0
Synonyms	SCHEMBL3929560 BDBM50100037 N-(1-Naphthylcarbonyl)-4-nitro-L-phenylalanine isopropyl ester (S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-phenyl)-propionic acid isopropyl ester
Inchi Key	BRRSSHDHRPOLFQ-NRFANRHFSA-N
Inchi ID	InChI=1S/C23H22N2O5/c1-15(2)30-23(27)21(14-16-10-12-18(13-11-16)25(28)29)24-22(26)20-9-5-7-17-6-3-4-8-19(17)20/h3-13,15,21H,14H2,1-2H3,(H,24,26)/t21-/m0/s1
PubChem CID	44281791
ChEMBL	CHEMBL33589
IUPHAR	N/A
BindingDB	50100037
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	21.0 nM	PMID11378373	BindingDB,ChEMBL

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