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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Leukotriene B4 receptor 1
Species	Homo sapiens (Human)
Gene	LTB4R
Synonym	BLT1 receptor BLTR Chemoattractant receptor-like 1 G-protein coupled receptor 16 GPR16 P2Y7 P2Y purinoceptor 7 LTB4-R1 LTB4-R 1 [ Show all ]
Disease	Inflammatory disease Inflammatory bowel disease Human immunodeficiency virus infection Pancreatic cancer Psoriasis Cystic fibrosis Osteoporosis Renal cancer Rheumatoid arthritis Asthma Allergy [ Show all ]
Length	352
Amino acid sequence	MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
UniProt	Q15722
Protein Data Bank	N/A
GPCR-HGmod model	Q15722
3D structure model	This predicted structure model is from GPCR-EXP Q15722.
BioLiP	N/A
Therapeutic Target Database	T59626
ChEMBL	CHEMBL3911
IUPHAR	267
DrugBank	BE0003490

Ligand

Name	CHEMBL171853
Molecular formula	C22H19NO2
IUPAC name	(E)-N-(2-methoxyphenyl)-3-(4-phenylphenyl)prop-2-enamide
Molecular weight	329.399
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.8
Synonyms	BDBM50291508 (E)-3-Biphenyl-4-yl-N-(2-methoxy-phenyl)-acrylamide
Inchi Key	BXKSETGKBADRAP-DTQAZKPQSA-N
Inchi ID	InChI=1S/C22H19NO2/c1-25-21-10-6-5-9-20(21)23-22(24)16-13-17-11-14-19(15-12-17)18-7-3-2-4-8-18/h2-16H,1H3,(H,23,24)/b16-13+
PubChem CID	44385257
ChEMBL	CHEMBL171853
IUPHAR	N/A
BindingDB	50291508
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<10000.0 nM	, Bioorg. Med. Chem. Lett., (1997) 7:7:949	BindingDB,ChEMBL

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