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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	C-C chemokine receptor type 3
Species	Homo sapiens (Human)
Gene	CCR3
Synonym	MIP-1alphaRL-2 (mouse) Eosinophil eotaxin receptor CKR3 chemokine (C-C motif) receptor 3 CD193 CCR3 CCR-3 CC-CKR-3 CC CKR3 C-C CKR-3 [ Show all ]
Disease	Allergic asthma Allergic rhinitis Asthma
Length	355
Amino acid sequence	MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
UniProt	P51677
Protein Data Bank	N/A
GPCR-HGmod model	P51677
3D structure model	This predicted structure model is from GPCR-EXP P51677.
BioLiP	N/A
Therapeutic Target Database	T02752, T85228
ChEMBL	CHEMBL3473
IUPHAR	60
DrugBank	N/A

Ligand

Name	CHEMBL290119
Molecular formula	C22H21NO4
IUPAC name	ethyl (2S)-3-(4-hydroxyphenyl)-2-(naphthalene-1-carbonylamino)propanoate
Molecular weight	363.413
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	4.4
Synonyms	BDBM50100025 N-(1-Naphthylcarbonyl)-L-tyrosine ethyl ester (S)-3-(4-Hydroxy-phenyl)-2-[(naphthalene-1-carbonyl)-amino]-propionic acid ethyl ester SCHEMBL3935277
Inchi Key	BYICFESQQALZGO-FQEVSTJZSA-N
Inchi ID	InChI=1S/C22H21NO4/c1-2-27-22(26)20(14-15-10-12-17(24)13-11-15)23-21(25)19-9-5-7-16-6-3-4-8-18(16)19/h3-13,20,24H,2,14H2,1H3,(H,23,25)/t20-/m0/s1
PubChem CID	9885355
ChEMBL	CHEMBL290119
IUPHAR	N/A
BindingDB	50100025
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	80.0 nM	PMID11378373	BindingDB,ChEMBL

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