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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptides B/W receptor type 1
Species	Homo sapiens (Human)
Gene	NPBWR1
Synonym	G protein-coupled receptor 7 G-protein coupled receptor 7 GPR7 neuropeptides B/W receptor type 1 NPBW1 receptor
Disease	N/A
Length	328
Amino acid sequence	MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProt	P48145
Protein Data Bank	N/A
GPCR-HGmod model	P48145
3D structure model	This predicted structure model is from GPCR-EXP P48145.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293293
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1441254
Molecular formula	C17H13ClN2O3
IUPAC name	5-chloro-4-(4-methoxyphenoxy)-2-phenylpyridazin-3-one
Molecular weight	328.752
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.6
Synonyms	MCULE-9419118685 ZINC1023864 5M-594S Oprea1_367843 42190-48-7 BDBM50401588 HMS2310B11 SR-01000692203 5-chloro-4-(4-methoxyphenoxy)-2-phenylpyridazin-3-one MLS000326761 AC1MCSS9 REGID_for_CID_2800329 5-chloro-4-(4-methoxyphenoxy)-2-phenyl-2,3-dihydropyridazin-3-one KS-000039SH SR-01000692203-3 MolPort-002-872-090 AKOS005095267 SMR000179332 5-chloro-4-(4-methoxyphenoxy)-2-phenyl-3(2H)-pyridazinone [ Show all ]
Inchi Key	CDMJYZVKNAEVQP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H13ClN2O3/c1-22-13-7-9-14(10-8-13)23-16-15(18)11-19-20(17(16)21)12-5-3-2-4-6-12/h2-11H,1H3
PubChem CID	2800329
ChEMBL	CHEMBL1441254
IUPHAR	N/A
BindingDB	50401588
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	13000.0 nM	PMID23079522	BindingDB,ChEMBL

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