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GPCR

NameHydroxycarboxylic acid receptor 2
SpeciesHomo sapiens (Human)
GeneHCAR2
SynonymG protein-coupled receptor 109A
PUMAG
Nicotinic acid receptor
Nic1
Niacr1
[ Show all ]
DiseaseType 2 diabetes
Hyperlipidaemia
Major depressive disorder
Cardiovascular disorder
Atherosclerosis
[ Show all ]
Length363
Amino acid sequenceMNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProtQ8TDS4
Protein Data BankN/A
GPCR-HGmod modelQ8TDS4
3D structure modelThis predicted structure model is from GPCR-EXP Q8TDS4.
BioLiPN/A
Therapeutic Target DatabaseT00864
ChEMBLCHEMBL3785
IUPHAR312
DrugBankBE0000635

Ligand

NameCHEMBL491242
Molecular formulaC26H28N4O
IUPAC name7-methyl-N-(3-phenylpropyl)-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide
Molecular weight412.537
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.1
SynonymsN/A
Inchi KeyCDPPEUVNQXWDKC-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H28N4O/c1-18(2)21-11-13-22(14-12-21)24-17-29-30-19(3)23(16-28-25(24)30)26(31)27-15-7-10-20-8-5-4-6-9-20/h4-6,8-9,11-14,16-18H,7,10,15H2,1-3H3,(H,27,31)
PubChem CID44580035
ChEMBLCHEMBL491242
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Activity0.0 %PMID18752940ChEMBL
Emax0.36 %PMID22420767ChEMBL
Emax22.0 %PMID22420767ChEMBL
Ratio134.0 -PMID22420767ChEMBL

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