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GPCR

NameMotilin receptor
SpeciesHomo sapiens (Human)
GeneMLNR
SynonymGPR38
G protein-coupled receptor 38
G-protein coupled receptor 38
MTLR1
MTLR
[ Show all ]
DiseaseGastrointestinal disorders; Gastroesophageal reflux disease
Irritable bowel syndrome
Gastrointestinal disease
Gastroesophageal reflux disease
Gastric motility disorder
[ Show all ]
Length412
Amino acid sequenceMGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
UniProtO43193
Protein Data BankN/A
GPCR-HGmod modelO43193
3D structure modelThis predicted structure model is from GPCR-EXP O43193.
BioLiPN/A
Therapeutic Target DatabaseT62306
ChEMBLCHEMBL2203
IUPHAR297
DrugBankBE0003521

Ligand

NameCHEMBL210899
Molecular formulaC40H45N5O6
IUPAC nameN-benzyl-N-[3-[[3-(2-morpholin-4-ylethoxy)-N-(phenylcarbamoyl)anilino]methyl]cyclohexyl]-3-nitrobenzamide
Molecular weight691.829
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP6.3
Synonymsrac-1-((3-(N-benzyl-3-nitrobenzamido)cyclohexyl)methyl)-1-(3-(2-morpholinoethoxy)phenyl)-3-phenylurea
BDBM50186104
Inchi KeyAEZJPJAVMUUMLW-UHFFFAOYSA-N
Inchi IDInChI=1S/C40H45N5O6/c46-39(33-13-8-18-37(27-33)45(48)49)43(29-31-10-3-1-4-11-31)35-16-7-12-32(26-35)30-44(40(47)41-34-14-5-2-6-15-34)36-17-9-19-38(28-36)51-25-22-42-20-23-50-24-21-42/h1-6,8-11,13-15,17-19,27-28,32,35H,7,12,16,20-26,29-30H2,(H,41,47)
PubChem CID10122749
ChEMBLN/A
IUPHARN/A
BindingDB50186104
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC501160.0 nMPMID16650762BindingDB

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