You can:
Name | P2Y purinoceptor 14 |
---|---|
Species | Mus musculus (Mouse) |
Gene | P2ry14 |
Synonym | G protein-coupled receptor 105 G-protein coupled receptor 105 GPR105 G protein coupled receptor for UDP-glucose P2Y purinoceptor 14 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 338 |
Amino acid sequence | MNNSTTTDPPNQPCSWNTLITKQIIPVLYGMVFITGLLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLGDSGLGPWQVNVFVCRVSAVIFYVNMYVSIVFFGLISFDRYYKIVKPLLTSIVQSVNYSKLLSVLVWMLMLLLAVPNIILTNQGVKEVTKIQCMELKNELGRKWHKASNYIFVSIFWVVFLLLIVFYTAITRKIFKSHLKSRKNSTSVKRKSSRNIFSIVLVFVVCFVPYHIARIPYTKSQTEGHYSCRTKETLLYAKEFTLLLSAANVCLDPIIYFFLCQPFREVLNKKLHMSLKVQNDLEVSKTKRENAIHESTDTL |
UniProt | Q9ESG6 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1770046 |
IUPHAR | 330 |
DrugBank | N/A |
Name | CHEMBL1771233 |
---|---|
Molecular formula | C26H22ClN5O |
IUPAC name | N-(4-chlorophenyl)-4-(2-methylphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide |
Molecular weight | 455.946 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 4.2 |
Synonyms | BDBM50343098 N-(4-chlorophenyl)-2-(pyridin-3-yl)-4-o-tolyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide |
Inchi Key | YWLJZLNSKJFNPI-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C26H22ClN5O/c1-17-5-2-3-7-21(17)24-22-16-32(26(33)29-20-10-8-19(27)9-11-20)14-12-23(22)30-25(31-24)18-6-4-13-28-15-18/h2-11,13,15H,12,14,16H2,1H3,(H,29,33) |
PubChem CID | 54583514 |
ChEMBL | CHEMBL1771233 |
IUPHAR | N/A |
BindingDB | 50343098 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 5800.0 nM | PMID21507642 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218