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GPCR

NameP2Y purinoceptor 11
SpeciesHomo sapiens (Human)
GeneP2RY11
SynonymP2Y11
P2Y11 receptor
purinergic receptor P2Y, G-protein coupled, 11
DiseaseN/A
Length374
Amino acid sequenceMAANVSGAKSCPANFLAAADDKLSGFQGDFLWPILVVEFLVAVASNGLALYRFSIRKQRPWHPAVVFSVQLAVSDLLCALTLPPLAAYLYPPKHWRYGEAACRLERFLFTCNLLGSVIFITCISLNRYLGIVHPFFARSHLRPKHAWAVSAAGWVLAALLAMPTLSFSHLKRPQQGAGNCSVARPEACIKCLGTADHGLAAYRAYSLVLAGLGCGLPLLLTLAAYGALGRAVLRSPGMTVAEKLRVAALVASGVALYASSYVPYHIMRVLNVDARRRWSTRCPSFADIAQATAALELGPYVGYQVMRGLMPLAFCVHPLLYMAAVPSLGCCCRHCPGYRDSWNPEDAKSTGQALPLNATAAPKPSEPQSRELSQ
UniProtQ96G91
Protein Data BankN/A
GPCR-HGmod modelQ96G91
3D structure modelThis predicted structure model is from GPCR-EXP Q96G91.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4867
IUPHAR327
DrugBankBE0005499

Ligand

NameAdenosine triphosphate
Molecular formulaC10H16N5O13P3
IUPAC name[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular weight507.181
Hydrogen bond acceptor17
Hydrogen bond donor7
XlogP-5.7
SynonymsST24045923
Adenosine 5'-triphosphate; Triphosphaden
UNII-8L70Q75FXE
Adenosintriphosphorsaeure
AK-54737
[ Show all ]
Inchi KeyZKHQWZAMYRWXGA-KQYNXXCUSA-N
Inchi IDInChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
PubChem CID5957
ChEMBLCHEMBL14249
IUPHAR1713
BindingDB50366480, 2
DrugBankDB00171

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
N/A N/ADrugBank
EC502511.89 - 63095.8 nMPMID10578132, PMID12761346, PMID12213051IUPHAR
EC503300.0 nMPMID21090681BindingDB,ChEMBL
EC506700.0 nMPMID26447940, PMID23751098BindingDB,ChEMBL
EC5017000.0 nMPMID12213051BindingDB,ChEMBL
EC5017300.0 nMPMID11985476BindingDB,ChEMBL

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