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GPCR

NameGlucose-dependent insulinotropic receptor
SpeciesMus musculus (Mouse)
GeneGpr119
SynonymG protein-coupled receptor 119
G-protein coupled receptor 119
G-protein coupled receptor 2
glucose-dependent insulinotropic receptor
GPCR2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length335
Amino acid sequenceMESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
UniProtQ7TQP3
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5263
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3354805
Molecular formulaC25H21F4N5O
IUPAC name[(3R)-3-cyclopropyl-3-[(3-fluorophenyl)methyl]-10-[6-(trifluoromethyl)pyridin-3-yl]-1,4,8,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),7,9,11-tetraen-11-yl]methanol
Molecular weight483.471
Hydrogen bond acceptor9
Hydrogen bond donor2
XlogP2.6
SynonymsBDBM50036672
Inchi KeyAPUDSMUVGAUEOX-XMMPIXPASA-N
Inchi IDInChI=1S/C25H21F4N5O/c26-18-3-1-2-14(8-18)9-24(17-5-6-17)22-16(12-32-24)11-31-23-21(19(13-35)33-34(22)23)15-4-7-20(30-10-15)25(27,28)29/h1-4,7-8,10-11,17,32,35H,5-6,9,12-13H2/t24-/m1/s1
PubChem CID118720432
ChEMBLCHEMBL3354805
IUPHARN/A
BindingDB50036672
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ratio0.12 -PMID25455488ChEMBL

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