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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Rattus norvegicus (Rat)
Gene	Gpr119
Synonym	G protein-coupled receptor 119 G-protein coupled receptor 119 G-protein coupled receptor 2 glucose-dependent insulinotropic receptor GPCR2 GPR119 [ Show all ]
Disease	N/A for non-human GPCRs
Length	468
Amino acid sequence	MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLCHMALGLLADGSTQPQIETLKGKEERKKVGRKTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDACDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTSSLVTGQTEQTPLKRANMSDPLRTCRG
UniProt	Q7TQN8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5262
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3326674
Molecular formula	C20H23FN4O5S2
IUPAC name	S-cyclopropyl 4-[5-fluoro-6-(2-methyl-6-methylsulfonylpyridin-3-yl)oxypyrimidin-4-yl]oxypiperidine-1-carbothioate
Molecular weight	482.545
Hydrogen bond acceptor	10
Hydrogen bond donor	0
XlogP	2.9
Synonyms	BDBM50056011
Inchi Key	GSUTYUFKAGTCBT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H23FN4O5S2/c1-12-15(5-6-16(24-12)32(2,27)28)30-19-17(21)18(22-11-23-19)29-13-7-9-25(10-8-13)20(26)31-14-3-4-14/h5-6,11,13-14H,3-4,7-10H2,1-2H3
PubChem CID	118711782
ChEMBL	CHEMBL3326674
IUPHAR	N/A
BindingDB	50056011
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	126.0 nM	PMID25088191	BindingDB,ChEMBL
Efficacy	80.0 %	PMID25088191	ChEMBL

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