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GPCR

NameUrotensin-2 receptor
SpeciesRattus norvegicus (Rat)
GeneUts2r
SynonymUT receptor
urotensin II receptor
UR-II-R
UR-2-R
UII-R1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length386
Amino acid sequenceMALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL
UniProtP49684
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4921
IUPHAR365
DrugBankN/A

Ligand

NameCHEMBL3577310
Molecular formulaC32H34N4O4
IUPAC name(3S,5R)-3-(4-aminobutyl)-1-[2-(4-hydroxyphenyl)ethyl]-2-oxo-5-(4-phenylphenyl)-3,4,5,6-tetrahydropyrrolo[3,2-e][1,4]diazepine-7-carboxylic acid
Molecular weight538.648
Hydrogen bond acceptor6
Hydrogen bond donor5
XlogP1.9
SynonymsBDBM50089666
J3.583.494J
(3S,5R)-5-(1,1'-Biphenyl-4-yl)-3-(4-aminobutyl)-1-(4-hydroxyphenethyl)-2-oxo-1,2,3,4,5,6-hexahydropyrrolo[3,2-e][1,4]diazepine-7-carboxylic acid
Inchi KeyDUNUPTQBHCOSBR-LITSAYRRSA-N
Inchi IDInChI=1S/C32H34N4O4/c33-18-5-4-8-26-31(38)36(19-17-21-9-15-25(37)16-10-21)28-20-27(32(39)40)35-30(28)29(34-26)24-13-11-23(12-14-24)22-6-2-1-3-7-22/h1-3,6-7,9-16,20,26,29,34-35,37H,4-5,8,17-19,33H2,(H,39,40)/t26-,29+/m0/s1
PubChem CID122177634
ChEMBLCHEMBL3577310
IUPHARN/A
BindingDB50089666
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC500.0 nMPMID25984647ChEMBL
EC500.0 nMPMID25984647BindingDB
EC503.467 nMPMID25984647ChEMBL
EC503.5 nMPMID25984647BindingDB,ChEMBL
EC504.467 nMPMID25984647ChEMBL
EC504.5 nMPMID25984647BindingDB,ChEMBL
EC5019.0 nMPMID25984647BindingDB
EC5019.4 nMPMID25984647ChEMBL
EC5019.5 nMPMID25984647ChEMBL
EC501000000000.0 nMPMID25984647BindingDB,ChEMBL
Emax0.0 %PMID25984647ChEMBL
Emax63.0 %PMID25984647ChEMBL
Emax92.0 %PMID25984647ChEMBL
Emax185.0 %PMID25984647ChEMBL
Kb2900.0 nMPMID25984647ChEMBL
pKb5.54 -PMID25984647ChEMBL

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