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GLASS

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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	MLS000045863
Molecular formula	C19H16FN3O2
IUPAC name	6-(2,3-dihydroindol-1-yl)-3-[(4-fluorophenyl)methyl]-1H-pyrimidine-2,4-dione
Molecular weight	337.354
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.7
Synonyms	IDI1_005618 AC1MMEXE SMR000016627 CHEMBL1518089 HMS1388J17 6-(2,3-dihydroindol-1-yl)-3-[(4-fluorophenyl)methyl]-1H-pyrimidine-2,4-dione BDBM37700 3-(4-fluorobenzyl)-6-indolin-1-yl-uracil ChemDiv2_006903 HMS2486D23 AB00411927-03 MLS000102316 cid_3237685 [ Show all ]
Inchi Key	AGBZJWQTKDBXCI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H16FN3O2/c20-15-7-5-13(6-8-15)12-23-18(24)11-17(21-19(23)25)22-10-9-14-3-1-2-4-16(14)22/h1-8,11H,9-10,12H2,(H,21,25)
PubChem CID	3237685
ChEMBL	CHEMBL1518089
IUPHAR	N/A
BindingDB	37700
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<66700.0 nM	N/A	BindingDB
Ki	<43700.0 nM	N/A	BindingDB
Ki	<66700.0 nM	PubChem BioAssay data set	ChEMBL

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