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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279135
Molecular formula	C22H26FNO4S
IUPAC name	4-[[benzylsulfonyl-[(4-fluorophenyl)methyl]amino]methyl]cyclohexane-1-carboxylic acid
Molecular weight	419.511
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.6
Synonyms	CHEMBL3909212 BJQSFVUCCKFJTR-UHFFFAOYSA-N 4-((N-(4-fluorobenzyl)-1-phenylmethylsulfonamido)methyl)-cyclohexanecarboxylic acid US9247759, 5-24 BDBM211102
Inchi Key	BJQSFVUCCKFJTR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H26FNO4S/c23-21-12-8-18(9-13-21)15-24(14-17-6-10-20(11-7-17)22(25)26)29(27,28)16-19-4-2-1-3-5-19/h1-5,8-9,12-13,17,20H,6-7,10-11,14-16H2,(H,25,26)
PubChem CID	57450324
ChEMBL	CHEMBL3909212
IUPHAR	N/A
BindingDB	211102
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	9570.0 nM	None	ChEMBL
IC50	9570.0 nM	N/A	BindingDB

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