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GLASS

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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Oprea1_007249
Molecular formula	C21H21NO6S
IUPAC name	4-[(4-ethoxyphenyl)methyl-(furan-2-ylmethyl)sulfamoyl]benzoic acid
Molecular weight	415.46
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.0
Synonyms	SCHEMBL1279074 CHEMBL3938183 US9247759, 5-3 BDBM211082
Inchi Key	MPFRIPJFKIRONX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H21NO6S/c1-2-27-18-9-5-16(6-10-18)14-22(15-19-4-3-13-28-19)29(25,26)20-11-7-17(8-12-20)21(23)24/h3-13H,2,14-15H2,1H3,(H,23,24)
PubChem CID	1169522
ChEMBL	CHEMBL3938183
IUPHAR	N/A
BindingDB	211082
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3000.0 nM	None	ChEMBL
IC50	3000.0 nM	N/A	BindingDB

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