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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Cysteinyl leukotriene receptor 2
Species	Homo sapiens (Human)
Gene	CYSLTR2
Synonym	CysLTR2 CysLT2 receptor LTC4 HPN321 hGPCR21 HG57 G-protein coupled receptor HG57 CYSLT2R G-protein coupled receptor GPCR21 [ Show all ]
Disease	Unspecified Asthma
Length	346
Amino acid sequence	MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
UniProt	Q9NS75
Protein Data Bank	N/A
GPCR-HGmod model	Q9NS75
3D structure model	This predicted structure model is from GPCR-EXP Q9NS75.
BioLiP	N/A
Therapeutic Target Database	T74238
ChEMBL	CHEMBL4330
IUPHAR	270
DrugBank	BE0000099

Ligand

Name	CHEMBL3809152
Molecular formula	C17H17Cl2NO4
IUPAC name	4,6-dichloro-3-[(E)-3-oxo-3-pentoxyprop-1-enyl]-1H-indole-2-carboxylic acid
Molecular weight	370.226
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	5.2
Synonyms	BDBM50172354
Inchi Key	AGDQVJZTCVKLOH-AATRIKPKSA-N
Inchi ID	InChI=1S/C17H17Cl2NO4/c1-2-3-4-7-24-14(21)6-5-11-15-12(19)8-10(18)9-13(15)20-16(11)17(22)23/h5-6,8-9,20H,2-4,7H2,1H3,(H,22,23)/b6-5+
PubChem CID	127043411
ChEMBL	CHEMBL3809152
IUPHAR	N/A
BindingDB	50172354
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<100000.0 nM	PMID26985325	BindingDB,ChEMBL

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