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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	C-C chemokine receptor type 3
Species	Homo sapiens (Human)
Gene	CCR3
Synonym	MIP-1alphaRL-2 (mouse) Eosinophil eotaxin receptor CKR3 chemokine (C-C motif) receptor 3 CD193 CCR3 CCR-3 CC-CKR-3 CC CKR3 C-C CKR-3 [ Show all ]
Disease	Allergic asthma Allergic rhinitis Asthma
Length	355
Amino acid sequence	MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
UniProt	P51677
Protein Data Bank	N/A
GPCR-HGmod model	P51677
3D structure model	This predicted structure model is from GPCR-EXP P51677.
BioLiP	N/A
Therapeutic Target Database	T02752, T85228
ChEMBL	CHEMBL3473
IUPHAR	60
DrugBank	N/A

Ligand

Name	CHEMBL194435
Molecular formula	C29H38N4
IUPAC name	N,N-dimethyl-4-[2-[2-(4-methylphenyl)ethylamino]-1-(4-phenylpiperazin-1-yl)ethyl]aniline
Molecular weight	442.651
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.4
Synonyms	SCHEMBL18840818 BDBM50162371 Dimethyl-{4-[1-(4-phenyl-piperazin-1-yl)-2-(2-p-tolyl-ethylamino)-ethyl]-phenyl}-amine
Inchi Key	AGVWRUHDPWHVJF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C29H38N4/c1-24-9-11-25(12-10-24)17-18-30-23-29(26-13-15-27(16-14-26)31(2)3)33-21-19-32(20-22-33)28-7-5-4-6-8-28/h4-16,29-30H,17-23H2,1-3H3
PubChem CID	44400944
ChEMBL	CHEMBL194435
IUPHAR	N/A
BindingDB	50162371
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	435.0 nM	PMID15743194	ChEMBL
Ki	435.0 nM	PMID15743194	BindingDB

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