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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Vasoactive intestinal polypeptide receptor 2
Species	Homo sapiens (Human)
Gene	VIPR2
Synonym	VPAC2 VIP-R-2 VIP and PACAP receptor 2 PVR3 Pituitary adenylate cyclase-activating polypeptide type III receptor PACAP-R3 PACAP-R-3 PACAP type III receptor Helodermin-preferring VIP receptor VPAC2 receptor [ Show all ]
Disease	Unspecified Chronic obstructive pulmonary disease Hypertension
Length	438
Amino acid sequence	MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI
UniProt	P41587
Protein Data Bank	N/A
GPCR-HGmod model	P41587
3D structure model	This predicted structure model is from GPCR-EXP P41587.
BioLiP	N/A
Therapeutic Target Database	T06182
ChEMBL	CHEMBL4532
IUPHAR	372
DrugBank	N/A

Ligand

Name	CHEMBL3890096
Molecular formula	C30H34N2O7S
IUPAC name	(2R,4S)-2-benzyl-5-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonylamino)-4-hydroxy-N-[(1S,2S)-2-methoxy-2,3-dihydro-1H-inden-1-yl]pentanamide
Molecular weight	566.669
Hydrogen bond acceptor	8
Hydrogen bond donor	3
XlogP	3.1
Synonyms	SCHEMBL17038283
Inchi Key	BYVNRPRZHJGNSB-WGTZDZHJSA-N
Inchi ID	InChI=1S/C30H34N2O7S/c1-37-28-17-21-9-5-6-10-25(21)29(28)32-30(34)22(15-20-7-3-2-4-8-20)16-23(33)19-31-40(35,36)24-11-12-26-27(18-24)39-14-13-38-26/h2-12,18,22-23,28-29,31,33H,13-17,19H2,1H3,(H,32,34)/t22-,23+,28+,29+/m1/s1
PubChem CID	118334931
ChEMBL	CHEMBL3890096
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	6000.0 nM	None	ChEMBL
Inhibition	28.1 %	None	ChEMBL

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