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GPCR

NameVasoactive intestinal polypeptide receptor 2
SpeciesHomo sapiens (Human)
GeneVIPR2
SynonymVPAC2
VIP-R-2
VIP and PACAP receptor 2
PVR3
Pituitary adenylate cyclase-activating polypeptide type III receptor
[ Show all ]
DiseaseUnspecified
Chronic obstructive pulmonary disease
Hypertension
Length438
Amino acid sequenceMRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI
UniProtP41587
Protein Data BankN/A
GPCR-HGmod modelP41587
3D structure modelThis predicted structure model is from GPCR-EXP P41587.
BioLiPN/A
Therapeutic Target DatabaseT06182
ChEMBLCHEMBL4532
IUPHAR372
DrugBankN/A

Ligand

NameCHEMBL3939316
Molecular formulaC32H41N3O5S
IUPAC name(2R,4S)-2-benzyl-4-hydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5-[[4-(pentylamino)phenyl]sulfonylamino]pentanamide
Molecular weight579.756
Hydrogen bond acceptor7
Hydrogen bond donor5
XlogP4.6
SynonymsSCHEMBL17038245
Inchi KeyCXFIGBVPSUSWQF-XSVIJKGOSA-N
Inchi IDInChI=1S/C32H41N3O5S/c1-2-3-9-18-33-26-14-16-28(17-15-26)41(39,40)34-22-27(36)20-25(19-23-10-5-4-6-11-23)32(38)35-31-29-13-8-7-12-24(29)21-30(31)37/h4-8,10-17,25,27,30-31,33-34,36-37H,2-3,9,18-22H2,1H3,(H,35,38)/t25-,27+,30-,31+/m1/s1
PubChem CID118334893
ChEMBLCHEMBL3939316
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition2.3 %NoneChEMBL
Inhibition2.8 %NoneChEMBL
Inhibition10.8 %NoneChEMBL
Inhibition11.3 %NoneChEMBL
Inhibition19.1 %NoneChEMBL

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