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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Vasoactive intestinal polypeptide receptor 2
Species	Homo sapiens (Human)
Gene	VIPR2
Synonym	VPAC2 VIP-R-2 VIP and PACAP receptor 2 PVR3 Pituitary adenylate cyclase-activating polypeptide type III receptor PACAP-R3 PACAP-R-3 PACAP type III receptor Helodermin-preferring VIP receptor VPAC2 receptor [ Show all ]
Disease	Unspecified Chronic obstructive pulmonary disease Hypertension
Length	438
Amino acid sequence	MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI
UniProt	P41587
Protein Data Bank	N/A
GPCR-HGmod model	P41587
3D structure model	This predicted structure model is from GPCR-EXP P41587.
BioLiP	N/A
Therapeutic Target Database	T06182
ChEMBL	CHEMBL4532
IUPHAR	372
DrugBank	N/A

Ligand

Name	CHEMBL3981373
Molecular formula	C27H29N3O7S
IUPAC name	(2R,4S)-2-benzyl-4-hydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5-[(3-nitrophenyl)sulfonylamino]pentanamide
Molecular weight	539.603
Hydrogen bond acceptor	8
Hydrogen bond donor	4
XlogP	2.6
Synonyms	SCHEMBL17038202
Inchi Key	FUAUYTZIGSIVPW-VAXWOWNTSA-N
Inchi ID	InChI=1S/C27H29N3O7S/c31-22(17-28-38(36,37)23-11-6-10-21(16-23)30(34)35)14-20(13-18-7-2-1-3-8-18)27(33)29-26-24-12-5-4-9-19(24)15-25(26)32/h1-12,16,20,22,25-26,28,31-32H,13-15,17H2,(H,29,33)/t20-,22+,25-,26+/m1/s1
PubChem CID	118334850
ChEMBL	CHEMBL3981373
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	15.2 %	None	ChEMBL
Inhibition	18.4 %	None	ChEMBL
Inhibition	21.3 %	None	ChEMBL
Inhibition	24.2 %	None	ChEMBL
Inhibition	33.4 %	None	ChEMBL
Inhibition	35.1 %	None	ChEMBL

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