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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Free fatty acid receptor 4
Species	Homo sapiens (Human)
Gene	FFAR4
Synonym	PGR4 Omega-3 fatty acid receptor 1 O3FAR1 GT01 GPR129 GPR120 G-protein-coupled receptor GT01 G-protein coupled receptor PGR4 FFA4 receptor G-protein coupled receptor 129 G-protein coupled receptor 120 G protein-coupled receptor 129 G protein-coupled receptor 120 G-protein coupled receptor GT01 [ Show all ]
Disease	N/A
Length	377
Amino acid sequence	MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQTSEHLLDARAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
UniProt	Q5NUL3
Protein Data Bank	N/A
GPCR-HGmod model	Q5NUL3
3D structure model	This predicted structure model is from GPCR-EXP Q5NUL3.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5339
IUPHAR	127
DrugBank	BE0003399

Ligand

Name	CHEMBL3901994
Molecular formula	C18H22ClF2NO2
IUPAC name	2-[3-(3-chloro-2,5-difluorophenyl)-3-azaspiro[5.5]undecan-9-yl]acetic acid
Molecular weight	357.826
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	5.2
Synonyms	BDBM50208146 SCHEMBL16483248
Inchi Key	GVMZIQCXQRZWJK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H22ClF2NO2/c19-14-10-13(20)11-15(17(14)21)22-7-5-18(6-8-22)3-1-12(2-4-18)9-16(23)24/h10-12H,1-9H2,(H,23,24)
PubChem CID	73777175
ChEMBL	CHEMBL3901994
IUPHAR	N/A
BindingDB	50208146
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	420.0 nM	PMID28105274	BindingDB,ChEMBL
EC50	1400.0 nM	PMID28105274	ChEMBL
EC50	2148.0 nM	N/A	BindingDB

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