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GPCR

NameVasoactive intestinal polypeptide receptor 2
SpeciesHomo sapiens (Human)
GeneVIPR2
SynonymVPAC2
VIP-R-2
VIP and PACAP receptor 2
PVR3
Pituitary adenylate cyclase-activating polypeptide type III receptor
[ Show all ]
DiseaseUnspecified
Chronic obstructive pulmonary disease
Hypertension
Length438
Amino acid sequenceMRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI
UniProtP41587
Protein Data BankN/A
GPCR-HGmod modelP41587
3D structure modelThis predicted structure model is from GPCR-EXP P41587.
BioLiPN/A
Therapeutic Target DatabaseT06182
ChEMBLCHEMBL4532
IUPHAR372
DrugBankN/A

Ligand

NameCHEMBL3951458
Molecular formulaC29H31ClN2O4
IUPAC name(2R,4S)-2-benzyl-5-[[2-(3-chlorophenyl)acetyl]amino]-4-hydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
Molecular weight507.027
Hydrogen bond acceptor4
Hydrogen bond donor4
XlogP3.7
SynonymsSCHEMBL17038238
Inchi KeyKQTSYYDLSVBAOA-PYWQUBSBSA-N
Inchi IDInChI=1S/C29H31ClN2O4/c30-23-11-6-9-20(14-23)15-27(35)31-18-24(33)16-22(13-19-7-2-1-3-8-19)29(36)32-28-25-12-5-4-10-21(25)17-26(28)34/h1-12,14,22,24,26,28,33-34H,13,15-18H2,(H,31,35)(H,32,36)/t22-,24+,26-,28+/m1/s1
PubChem CID118334886
ChEMBLCHEMBL3951458
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition11.3 %NoneChEMBL
Inhibition14.4 %NoneChEMBL
Inhibition16.0 %NoneChEMBL
Inhibition17.2 %NoneChEMBL
Inhibition20.1 %NoneChEMBL
Inhibition26.5 %NoneChEMBL

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