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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Vasoactive intestinal polypeptide receptor 2
Species	Homo sapiens (Human)
Gene	VIPR2
Synonym	VPAC2 VIP-R-2 VIP and PACAP receptor 2 PVR3 Pituitary adenylate cyclase-activating polypeptide type III receptor PACAP-R3 PACAP-R-3 PACAP type III receptor Helodermin-preferring VIP receptor VPAC2 receptor [ Show all ]
Disease	Unspecified Chronic obstructive pulmonary disease Hypertension
Length	438
Amino acid sequence	MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI
UniProt	P41587
Protein Data Bank	N/A
GPCR-HGmod model	P41587
3D structure model	This predicted structure model is from GPCR-EXP P41587.
BioLiP	N/A
Therapeutic Target Database	T06182
ChEMBL	CHEMBL4532
IUPHAR	372
DrugBank	N/A

Ligand

Name	CHEMBL3982346
Molecular formula	C28H30N2O7S
IUPAC name	(2R,4S)-5-(1,3-benzodioxol-5-ylsulfonylamino)-2-benzyl-4-hydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
Molecular weight	538.615
Hydrogen bond acceptor	8
Hydrogen bond donor	4
XlogP	2.6
Synonyms	SCHEMBL15714535
Inchi Key	LHNJGKOVXCYQPW-CFQDUWEQSA-N
Inchi ID	InChI=1S/C28H30N2O7S/c31-21(16-29-38(34,35)22-10-11-25-26(15-22)37-17-36-25)13-20(12-18-6-2-1-3-7-18)28(33)30-27-23-9-5-4-8-19(23)14-24(27)32/h1-11,15,20-21,24,27,29,31-32H,12-14,16-17H2,(H,30,33)/t20-,21+,24-,27+/m1/s1
PubChem CID	90154607
ChEMBL	CHEMBL3982346
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3810.0 nM	None	ChEMBL

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