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GPCR

NameVasoactive intestinal polypeptide receptor 2
SpeciesHomo sapiens (Human)
GeneVIPR2
SynonymVPAC2
VIP-R-2
VIP and PACAP receptor 2
PVR3
Pituitary adenylate cyclase-activating polypeptide type III receptor
[ Show all ]
DiseaseUnspecified
Chronic obstructive pulmonary disease
Hypertension
Length438
Amino acid sequenceMRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI
UniProtP41587
Protein Data BankN/A
GPCR-HGmod modelP41587
3D structure modelThis predicted structure model is from GPCR-EXP P41587.
BioLiPN/A
Therapeutic Target DatabaseT06182
ChEMBLCHEMBL4532
IUPHAR372
DrugBankN/A

Ligand

NameCHEMBL3952350
Molecular formulaC27H29N3O4
IUPAC nameN-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]pyridine-2-carboxamide
Molecular weight459.546
Hydrogen bond acceptor5
Hydrogen bond donor4
XlogP2.4
SynonymsSCHEMBL15713504
Inchi KeyNSNXSEDSTAXTCS-WIVXBSKCSA-N
Inchi IDInChI=1S/C27H29N3O4/c31-21(17-29-27(34)23-12-6-7-13-28-23)15-20(14-18-8-2-1-3-9-18)26(33)30-25-22-11-5-4-10-19(22)16-24(25)32/h1-13,20-21,24-25,31-32H,14-17H2,(H,29,34)(H,30,33)/t20-,21+,24-,25+/m1/s1
PubChem CID90153764
ChEMBLCHEMBL3952350
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition5.5 %NoneChEMBL
Inhibition6.1 %NoneChEMBL
Inhibition14.9 %NoneChEMBL
Inhibition17.7 %NoneChEMBL
Inhibition20.3 %NoneChEMBL
Inhibition32.7 %NoneChEMBL

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