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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Vasoactive intestinal polypeptide receptor 2
Species	Homo sapiens (Human)
Gene	VIPR2
Synonym	VPAC2 VIP-R-2 VIP and PACAP receptor 2 PVR3 Pituitary adenylate cyclase-activating polypeptide type III receptor PACAP-R3 PACAP-R-3 PACAP type III receptor Helodermin-preferring VIP receptor VPAC2 receptor [ Show all ]
Disease	Unspecified Chronic obstructive pulmonary disease Hypertension
Length	438
Amino acid sequence	MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI
UniProt	P41587
Protein Data Bank	N/A
GPCR-HGmod model	P41587
3D structure model	This predicted structure model is from GPCR-EXP P41587.
BioLiP	N/A
Therapeutic Target Database	T06182
ChEMBL	CHEMBL4532
IUPHAR	372
DrugBank	N/A

Ligand

Name	CHEMBL3918682
Molecular formula	C22H28N2O5S
IUPAC name	(2R,4S)-2-benzyl-4-hydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5-(methanesulfonamido)pentanamide
Molecular weight	432.535
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	1.3
Synonyms	SCHEMBL17038205
Inchi Key	PLVDSROZZVHSLN-JYRKZWEQSA-N
Inchi ID	InChI=1S/C22H28N2O5S/c1-30(28,29)23-14-18(25)12-17(11-15-7-3-2-4-8-15)22(27)24-21-19-10-6-5-9-16(19)13-20(21)26/h2-10,17-18,20-21,23,25-26H,11-14H2,1H3,(H,24,27)/t17-,18+,20-,21+/m1/s1
PubChem CID	118334853
ChEMBL	CHEMBL3918682
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	17.3 %	None	ChEMBL
Inhibition	18.5 %	None	ChEMBL
Inhibition	21.4 %	None	ChEMBL
Inhibition	21.9 %	None	ChEMBL
Inhibition	23.4 %	None	ChEMBL
Inhibition	31.6 %	None	ChEMBL

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