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GPCR

NameRYamide receptor
SpeciesDrosophila melanogaster (Fruit fly)
GeneRYa-R
SynonymNeuropeptide Y-like receptor {ECO:0000303|PubMed:1370455}
NPY-R {ECO:0000303|PubMed:1370455}
DiseaseN/A for non-human GPCRs
Length464
Amino acid sequenceMEHHNSHLLPGGSEKMYYIAHQQPMLRNEDDNYQEGYFIRPDPASLIYNTTALPADDEGSNYGYGSTTTLSGLQFETYNITVMMNFSCDDYDLLSEDMWSSAYFKIIVYMLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNYFIASLAIGDILMSFFCVPSSFISLFILNYWPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPLKPRITKRYATFIIAGVWFIALATALPIPIVSGLDIPMSPWHTKCEKYICREMWPSRTQEYYYTLSLFALQFVVPLGVLIFTYARITIRVWAKRPPGEAETNRDQRMARSKRKMVKMMLTVVIVFTCCWLPFNILQLLLNDEEFAHWDPLPYVWFAFHWLAMSHCCYNPIIYCYMNARFRSGFVQLMHRMPGLRRWCCLRSVGDRMNATSGTGPALPLNRMNTSTTYISARRKPRATSLRANPLSCGETSPLR
UniProtP25931
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3879848
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3974271
Molecular formulaC18H33N5S
IUPAC name(6S)-6-(4-aminobutyl)-2,4-bis(2-methylpropyl)-6,7-dihydro-5H-pyrazolo[4,3-e][1,4]diazepine-8-thione
Molecular weight351.557
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP3.1
SynonymsBDBM50192748
SCHEMBL3468409
Inchi KeySRDGVWFRHBVJPL-HNNXBMFYSA-N
Inchi IDInChI=1S/C18H33N5S/c1-13(2)9-22-11-15(7-5-6-8-19)20-18(24)17-16(22)12-23(21-17)10-14(3)4/h12-15H,5-11,19H2,1-4H3,(H,20,24)/t15-/m0/s1
PubChem CID46236234
ChEMBLCHEMBL3974271
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity40.0 %PMID27597247ChEMBL
EC506800.0 nMPMID27597247ChEMBL

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