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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Probable G-protein coupled receptor 142
Species	Mus musculus (Mouse)
Gene	Gpr142
Synonym	AXOR103 G-protein coupled receptor PGR2 GPR142 KIF19
Disease	N/A for non-human GPCRs
Length	365
Amino acid sequence	MHLNSNPNSYICDAYQHADLLWSLSPHVLTKAVQPQVTLLPTVNGSNPRYDGVDGHWPESPERSPCVAGIIPVIYYSVLLSLGLPVALARLAARTRKPSYHYLLALTASDIVTQVIIVFVGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLALDIANMLAMLNTEVNFGLYCFISKTFRATVRQVICDVHMACALKSQPKQTVVELMLKSVGTEL
UniProt	Q7TQN9
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2069162
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3923863
Molecular formula	C22H20Cl2N6O
IUPAC name	N-(2,3-dichlorophenyl)-2-methyl-2-[4-[4-(2-methylimidazol-1-yl)phenyl]triazol-1-yl]propanamide
Molecular weight	455.343
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.4
Synonyms	BDBM50201580
Inchi Key	WXJZLQMCWDHDLZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H20Cl2N6O/c1-14-25-11-12-29(14)16-9-7-15(8-10-16)19-13-30(28-27-19)22(2,3)21(31)26-18-6-4-5-17(23)20(18)24/h4-13H,1-3H3,(H,26,31)
PubChem CID	134141648
ChEMBL	CHEMBL3923863
IUPHAR	N/A
BindingDB	50201580
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	112.0 %	PMID27994747	ChEMBL
EC50	801.0 nM	PMID27994747	BindingDB,ChEMBL

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