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GLASS

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GPCR

Name	fMet-Leu-Phe receptor
Species	Mus musculus (Mouse)
Gene	Fpr1
Synonym	N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R NFPR [ Show all ]
Disease	N/A for non-human GPCRs
Length	364
Amino acid sequence	MDTNMSLLMNKSAVNLMNVSGSTQSVSAGYIVLDVFSYLIFAVTFVLGVLGNGLVIWVAGFRMKHTVTTISYLNLAIADFCFTSTLPFYIASMVMGGHWPFGWFMCKFIYTVIDINLFGSVFLIALIALDRCICVLHPVWAQNHRTVSLAKKVIIVPWICAFLLTLPVIIRLTTVPNSRLGPGKTACTFDFSPWTKDPVEKRKVAVTMLTVRGIIRFIIGFSTPMSIVAICYGLITTKIHRQGLIKSSRPLRVLSFVVAAFFLCWCPFQVVALISTIQVRERLKNMTPGIVTALKITSPLAFFNSCLNPMLYVFMGQDFRERLIHSLPASLERALTEDSAQTSDTGTNLGTNSTSLSENTLNAM
UniProt	P33766
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1770037
IUPHAR	222
DrugBank	N/A

Ligand

Name	59880-97-6
Molecular formula	C21H31N3O5S
IUPAC name	(2S)-2-[[(2S)-2-[[(2S)-2-formamido-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid
Molecular weight	437.555
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	1.5
Synonyms	fMLF GTPL1022 MLS001361389 N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE (S)-2-[(S)-2-((S)-2-Formylamino-4-methylsulfanyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid B6888 Chemotactic peptide For-Met-Leu-Phe-OH KS-000019CN N-Formyl-L-methionyl-L-leucyl-L-phenylalanine SCHEMBL39529 34065-EP2311453A1 C11596 D0XF0A formyl-methionyl-leucyl-phenylalanine LS-193196 N-Formyl-Met-Leu-Phe, BioXtra, >=99.0% (TLC) (2S)-2-[[(2S)-2-[[(2S)-2-formamido-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid AC1L9EDZ fMet-Leu-Phe FMLP HMS2235B23 MLS002207097 n-formylmethionine-leucine-phenylalanine BDBM50050937 CS-6489 Formyl met leu phe L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)- N-Formyl-Met-Leu-Phe SMR000857394 CC-25639 DTXSID9041077 fMetLeuPhe FT-0640642 MFCD00036780 N-Formyl-methionyl-leucyl-phenylalanine (S)-2-((S)-2-((S)-2-Formamido-4-(methylthio)butanamido)-4-methylpentanamido)-3-phenylpropanoic acid AKOS024456858 CHEMBL267179 fMLP (misnomer but widely used) HY-P0224 MolPort-003-934-280 PRQROPMIIGLWRP-BZSNNMDCSA-N 34065-EP2295055A2 C-22333 D0M0YH formyl-Met-Leu-Phe L-Phenylalanine, N-formyl-L-methionyl-L-leucyl- N-Formyl-Met-Leu-Phe, >=97% (HPLC) ZINC4099172 CHEBI:53490 F-Met-leu-phe [ Show all ]
Inchi Key	PRQROPMIIGLWRP-BZSNNMDCSA-N
Inchi ID	InChI=1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
PubChem CID	443295
ChEMBL	CHEMBL267179
IUPHAR	1022
BindingDB	50050937
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	19952.6 nM	PMID10477558, PMID18606697	IUPHAR

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