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GPCR

Name	Probable G-protein coupled receptor 139
Species	Homo sapiens (Human)
Gene	GPR139
Synonym	G(q)-coupled orphan receptor GPRg1 G-protein-coupled receptor PGR3 GPR139 GPRG1
Disease	N/A
Length	353
Amino acid sequence	MEHTHAHLAANSSLSWWSPGSACGLGFVPVVYYSLLLCLGLPANILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILNMQMPQVPDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWTEDYISTSVHHVLIWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLALLNTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQYDKNGKPIKVSP
UniProt	Q6DWJ6
Protein Data Bank	N/A
GPCR-HGmod model	Q6DWJ6
3D structure model	This predicted structure model is from GPCR-EXP Q6DWJ6.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3632455
IUPHAR	130
DrugBank	N/A

Ligand

Name	L-tryptophan
Molecular formula	C11H12N2O2
IUPAC name	(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid
Molecular weight	204.229
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	-1.1
Synonyms	Lopac-T-0254 BP-13286 (S)-(-)-Tryptophan MFCD00064340 (s)-a-amino-b-indolepropionate NCGC00094437-04 DB-029986 (S)-alpha-Amino-beta-indolepropionic acid NSC757373 EH 121 1beta-3-Indolylalanine QIVBCDIJIAJPQS-VIFPVBQESA-N h-Trp-oh 2-Amino-3-indolylpropanoate SR-01000075590 Indole-3-propionic acid, alpha-amino- 80206-30-0 Tox21_501183 L-(-)-Tryptophane ACT08662 Tryptan L-beta-3-Indolylalanine alpha-Amino-3-indolepropionic acid, L- Tryptophan, L- L-Tryptophan premix L-Tryptophan, United States Pharmacopeia (USP) Reference Standard ANW-36308 UNII-8DUH1N11BX BDBM21974 Z1245635763 (-)-Tryptophan LS-1622 C00078 (S)-2-Amino-3-(1H-indol-3-yl)propanoic acid MolPort-044-812-611 CTK2H7431 (S)-a-Aminoindole-3-propionic acid NCGC00261868-01 DSSTox_CID_1419 (S)-Tryptophan Pacitron EU-0101183 1H-Indole-3-alanine, (S)- S(-)-1-alpha-Aminoindole-3-propionic acid HSDB 4142 3-(1H-indol-3-yl)-L-Alanine STR02722 KBio1_000457 AB00373874_05 trofan l-a-Aminoindole-3-propionic acid AK-50074 Tryptophan (L-Tryptophan) L-Tryptofan alpha-Amino-beta-(3-indolyl)-propionic acid Tryptophane L-Tryptophan, certified reference material, TraceCERT(R) L-Tryptophan,(S) L-Trytophane bmse000868 ZX-AT022248 (S)-(-)-2-Amino-3-(3-indolyl)propionic Acid M02943 CCRIS 617 (S)-a-Amino-1H-indole-3-propanoate NCGC00094437-02 D00020 (S)-alpha-amino-beta-(3-indolyl)-propionic acid NSC 13119 DTXSID5021419 151A3008-4CFE-40C9-AC0B-467EF0CB50EA Propionic acid, 2-amino-3-indol-3-yl- GM0674 2-Amino-3-(lH-indol-3-yl)-propanoic acid Sedanoct Indoe-3-propionic acid, alpha-amino- 73-22-3 Tox21_201246 L(-)-Tryptophan, 99% AC1L1M8F TRP-01 L-alpha-Aminoindole-3-propionic acid Alanine, 3-indol-3-yl- Tryptophan [USAN:INN] L-Tryptophan (JP15) AM82273 Tryptophanum [Latin] Ardeytropin UNII-N7U7BXP2OI component QIVBCDIJIAJPQS-VIFPVBQESA-N Lopac0_001183 BR-50074 (S)-1H-Indole-3-alanine MLS001056750 CHEMBL54976 (S)-a-Amino-b-indolepropionic acid NCGC00254424-01 DB00150 (S)-alpha-Aminoindole-3-propionate Optimax EINECS 200-795-6 1H-Indole-3-alanine RP26086 HMS3263N07 2-Amino-3-indolylpropanoic acid SR-01000075590-1 Kalma 8DUH1N11BX triptofano L-2-Amino-3-indolepropionic acid AI3-18478 tryptophan L-Trp alpha-Amino-3-Indoleproprionic Acid Tryptophan, L- (8CI) L-TRYPTOPHAN SIGMA GRADE L-Tryptophan, Vetec(TM) reagent grade, >=98% BIT0720 ZINC83315 (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid LS-185087 CAS-73-22-3 (S)-2-Amino-3-(3-indolyl)propionic acid NCGC00015994-01 D-2-Amino-3-indolepropionic acid (S)-alpha-Amino-1H-indole-3-propanoate NCI-C01729 DSSTox_GSID_21419 (S)-Tryptophan 1H-Indole-3-alanine, (S)- Pharmakon1600-01500600 F0001-2364 1H-Indole-3-propanoic acid, alpha-amino-, (S)- SB14997 HTS001390 3-Indol-3-ylalanine T 0254 KSC377I3D AB1007074 trp L-Alanine, 3-(1H-indol-3-yl)- AKOS015854052 Tryptophan (USP/INN) alpha-Aminoindole-3-propionic acid Tryptophane [French] L-Tryptophan, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 99.0-101.0% L-Tryptophane L-Ttp bmse001017 (S)-(-)-Tryptopha n MCULE-8004234494 CHEBI:16828 (S)-a-Amino-1H-indole-3-propanoic acid NCGC00094437-03 D05EJG (s)-alpha-amino-beta-indolepropionate NSC-757373 EC 200-795-6 154635-35-5 PubChem10984 GTPL717 2-amino-3-indol-3-ylpropionic acid SMR000326686 Indole-3-alanine 73T223 Tox21_300359 L-(-)-Tryptophan AC1Q4U80 tryptacin l-b-3-Indolylalanine alpha'-Amino-3-indolepropionic acid Tryptophan, European Pharmacopoeia (EP) Reference Standard L-Tryptophan (JP17) L-Tryptophan, reagent grade, >=98% (HPLC) AN-8742 trytophan AX8034769 UNII-X9U7434L7A component QIVBCDIJIAJPQS-VIFPVBQESA-N LP01183 C-48302 (S)-2-amino-3-(1H-Indol-3-yl)-propionic acid MolPort-001-794-499 CS-W020011 (S)-a-Aminoindole-3-propionate NCGC00258798-01 DivK1c_000457 (S)-alpha-Aminoindole-3-propionic acid OR28930 Epitope ID:136043 1H-Indole-3-alanine (VAN) RTC-066620 HMS501G19 2a4m ST2419449 KB-53414 A7403 Triptofano [Spanish] L-a-Amino-3-indolepropionic acid AJ-10635 Tryptophan (H-3) L-Trp-OH alpha-amino-beta-(3-indolyl)-pr opionic acid Tryptophan, L-(8CI) L-Tryptophan, BioUltra, >=99.5% (NT) L-Tryptophan, Vetec(TM), 98.5% L-Tryptophan, PharmaGrade, Ajinomoto, EP, JP, USP, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production, suitable for cell culture L-Trytophan bmse000050 ZX-AFC000605 (L)-TRYPTOPHAN Lyphan CCG-205257 (S)-2-Amino-3-(3-indolyl)propionic acid; L-\|A-Amino-3-indolepropionic acid NCGC00094437-01 D-Trp-OH (S)-alpha-Amino-1H-indole-3-propanoic acid NINDS_000457 DSSTox_RID_76152 1-beta-3-Indolylalanine Propionic acid, 2-amino-3-indol-3-yl FT-0627592 1qaw SCHEMBL7328 IDI1_000457 TC-066620 L(-)-Tryptophan AC-17050 TRP NH3+ COOH L-alpha-amino-3-indolepropionic acid Alanine, 3-indol-3-yl Tryptophan (VAN) L-Tryptophan (9CI) Alti-Tryptophan Tryptophanum [ Show all ]
Inchi Key	QIVBCDIJIAJPQS-VIFPVBQESA-N
Inchi ID	InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1
PubChem CID	6305
ChEMBL	CHEMBL54976
IUPHAR	717
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	220000.0 nM	PMID24826842	IUPHAR
IC50	26000.0 nM	PMID26349500	IUPHAR
Ki	738000.0 nM	PMID26349500	IUPHAR

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