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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Free fatty acid receptor 4
Species	Homo sapiens (Human)
Gene	FFAR4
Synonym	PGR4 Omega-3 fatty acid receptor 1 O3FAR1 GT01 GPR129 GPR120 G-protein-coupled receptor GT01 G-protein coupled receptor PGR4 FFA4 receptor G-protein coupled receptor 129 G-protein coupled receptor 120 G protein-coupled receptor 129 G protein-coupled receptor 120 G-protein coupled receptor GT01 [ Show all ]
Disease	N/A
Length	377
Amino acid sequence	MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQTSEHLLDARAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
UniProt	Q5NUL3
Protein Data Bank	N/A
GPCR-HGmod model	Q5NUL3
3D structure model	This predicted structure model is from GPCR-EXP Q5NUL3.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5339
IUPHAR	127
DrugBank	BE0003399

Ligand

Name	SCHEMBL16483225
Molecular formula	C19H25ClFNO2
IUPAC name	2-[3-(2-chloro-3-fluoro-5-methylphenyl)-3-azaspiro[5.5]undecan-9-yl]acetic acid
Molecular weight	353.862
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.4
Synonyms	US9708270, 37 BDBM261542
Inchi Key	IJZWCFNWZRZOCY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H25ClFNO2/c1-13-10-15(21)18(20)16(11-13)22-8-6-19(7-9-22)4-2-14(3-5-19)12-17(23)24/h10-11,14H,2-9,12H2,1H3,(H,23,24)
PubChem CID	73777158
ChEMBL	N/A
IUPHAR	N/A
BindingDB	261542
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2171.0 nM	N/A	BindingDB

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