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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Probable G-protein coupled receptor 142
Species	Homo sapiens (Human)
Gene	GPR142
Synonym	AXOR103 G-protein coupled receptor PGR2 GPR142 KIF19
Disease	N/A
Length	462
Amino acid sequence	MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
UniProt	Q7Z601
Protein Data Bank	N/A
GPCR-HGmod model	Q7Z601
3D structure model	This predicted structure model is from GPCR-EXP Q7Z601.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2069161
IUPHAR	132
DrugBank	N/A

Ligand

Name	CHEMBL2069498
Molecular formula	C27H26N4O2
IUPAC name	(2S)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenyl-2-(2-phenylethylamino)propanamide
Molecular weight	438.531
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	3.2
Synonyms	BDBM50390611
Inchi Key	DKCBDVYPDFSXEL-DEOSSOPVSA-N
Inchi ID	InChI=1S/C27H26N4O2/c32-26-25(18-23(19-30-26)22-12-14-28-15-13-22)31-27(33)24(17-21-9-5-2-6-10-21)29-16-11-20-7-3-1-4-8-20/h1-10,12-15,18-19,24,29H,11,16-17H2,(H,30,32)(H,31,33)/t24-/m0/s1
PubChem CID	70695055
ChEMBL	CHEMBL2069498
IUPHAR	N/A
BindingDB	50390611
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	780.0 nM	PMID22884988	BindingDB,ChEMBL
Emax	67.0 %	PMID22884988	ChEMBL

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