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GPCR

NameVasopressin V2 receptor
SpeciesRattus norvegicus (Rat)
GeneAvpr2
SynonymAVPR V2
Antidiuretic hormone receptor
ADHR
Renal-type arginine vasopressin receptor
V2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length371
Amino acid sequenceMLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
UniProtQ00788
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3766
IUPHAR368
DrugBankN/A

Ligand

NameCHEMBL274955
Molecular formulaC24H34N2O3S
IUPAC name(1S,2S,4R)-2-(aminomethyl)-7,7-dimethyl-1-(spiro[indene-1,4'-piperidine]-1'-ylsulfonylmethyl)bicyclo[2.2.1]heptan-2-ol
Molecular weight430.607
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.9
SynonymsBDBM50043144
2-aminomethyl-7,7-dimethyl-1-spiro[1H-indene-1,4''-(hexahydropyridine)]-1-ylsulfonylmethyl-(1S,2S,4R)-bicyclo[2.2.1]hept-2-yl alcohol
Inchi KeyDKSALKIFWFBTCZ-VEXUSMLFSA-N
Inchi IDInChI=1S/C24H34N2O3S/c1-21(2)19-8-10-23(21,24(27,15-19)16-25)17-30(28,29)26-13-11-22(12-14-26)9-7-18-5-3-4-6-20(18)22/h3-7,9,19,27H,8,10-17,25H2,1-2H3/t19-,23+,24-/m1/s1
PubChem CID10432863
ChEMBLCHEMBL274955
IUPHARN/A
BindingDB50043144
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50100000.0 nMPMID8258821BindingDB,ChEMBL

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