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GPCR

NameMotilin receptor
SpeciesHomo sapiens (Human)
GeneMLNR
SynonymGPR38
G protein-coupled receptor 38
G-protein coupled receptor 38
MTLR1
MTLR
[ Show all ]
DiseaseGastrointestinal disorders; Gastroesophageal reflux disease
Irritable bowel syndrome
Gastrointestinal disease
Gastroesophageal reflux disease
Gastric motility disorder
[ Show all ]
Length412
Amino acid sequenceMGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
UniProtO43193
Protein Data BankN/A
GPCR-HGmod modelO43193
3D structure modelThis predicted structure model is from GPCR-EXP O43193.
BioLiPN/A
Therapeutic Target DatabaseT62306
ChEMBLCHEMBL2203
IUPHAR297
DrugBankBE0003521

Ligand

NameSCHEMBL1704702
Molecular formulaC26H33F3N4O
IUPAC name2-[4-[[(3S)-3-methylpiperazin-1-yl]methyl]phenyl]-1-[4-[3-(trifluoromethyl)anilino]piperidin-1-yl]ethanone
Molecular weight474.572
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP4.0
SynonymsCHEMBL2364269
Inchi KeyDNXDIZDCMLZGSW-IBGZPJMESA-N
Inchi IDInChI=1S/C26H33F3N4O/c1-19-17-32(14-11-30-19)18-21-7-5-20(6-8-21)15-25(34)33-12-9-23(10-13-33)31-24-4-2-3-22(16-24)26(27,28)29/h2-8,16,19,23,30-31H,9-15,17-18H2,1H3/t19-/m0/s1
PubChem CID15984999
ChEMBLCHEMBL2364269
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC506.31 nMDOI: http://dx.doi.org/10.6019/CHEMBL2364262ChEMBL

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