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Name | Corticotropin-releasing factor receptor 1 |
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Species | Homo sapiens (Human) |
Gene | CRHR1 |
Synonym | CRHR CRH-R1 CRH-R-1 CRFR1 CRFR-1 [ Show all ] |
Disease | Major depressive disorder; Severe mood disorder Depression; Anxiety Depression Irritable bowel syndrome Anxiety disorder; Depression [ Show all ] |
Length | 444 |
Amino acid sequence | MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV |
UniProt | P34998 |
Protein Data Bank | 4z9g, 4k5y |
GPCR-HGmod model | P34998 |
3D structure model | This structure is from PDB ID 4z9g. |
BioLiP | BL0350036,BL0350037,BL0350038, BL0251208 |
Therapeutic Target Database | T45262 |
ChEMBL | CHEMBL1800 |
IUPHAR | 212 |
DrugBank | BE0008658 |
Name | UNII-874OEY3JEJ |
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Molecular formula | C22H26Cl2N4 |
IUPAC name | 3-(2,4-dichlorophenyl)-9-heptan-4-yl-6-methyl-1,2,5,9-tetrazatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7-tetraene |
Molecular weight | 417.378 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | 6.3 |
Synonyms | 268545-87-5 NBI 34041 874OEY3JEJ SB723620 1-(2,4-Dichlorophenyl)-5-(heptan-4-yl)-7-methyl-4,5-dihydro-3H-2,2a,5,8-tetraazaacenaphthylene [ Show all ] |
Inchi Key | AKLMUGFDGONMAA-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H26Cl2N4/c1-4-6-16(7-5-2)27-10-11-28-22-19(27)12-14(3)25-21(22)20(26-28)17-9-8-15(23)13-18(17)24/h8-9,12-13,16H,4-7,10-11H2,1-3H3 |
PubChem CID | 9888194 |
ChEMBL | CHEMBL188907 |
IUPHAR | N/A |
BindingDB | 50171325 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 4.0 nM | PMID21618986 | BindingDB,ChEMBL |
Ki | 4.5 nM | PMID16078829 | BindingDB,ChEMBL |
Ki | 5.012 nM | PMID16134945 | ChEMBL |
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