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Name | Vasoactive intestinal polypeptide receptor 2 |
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Species | Homo sapiens (Human) |
Gene | VIPR2 |
Synonym | VPAC2 VIP-R-2 VIP and PACAP receptor 2 PVR3 Pituitary adenylate cyclase-activating polypeptide type III receptor [ Show all ] |
Disease | Unspecified Chronic obstructive pulmonary disease Hypertension |
Length | 438 |
Amino acid sequence | MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI |
UniProt | P41587 |
Protein Data Bank | N/A |
GPCR-HGmod model | P41587 |
3D structure model | This predicted structure model is from GPCR-EXP P41587. |
BioLiP | N/A |
Therapeutic Target Database | T06182 |
ChEMBL | CHEMBL4532 |
IUPHAR | 372 |
DrugBank | N/A |
Name | CID 76313784 |
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Molecular formula | C155H248N46O46 |
IUPAC name | (2S)-6-amino-2-[[2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,5S,8S,11S,20S)-20-[[(2S)-5-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-carboxypropanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-8-(4-aminobutyl)-2-methyl-3,6,9,17,21-pentaoxo-5-propan-2-yl-1,4,7,10,16-pentazacyclohenicosane-11-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]acetyl]amino]hexanoic acid |
Molecular weight | 3491.97 |
Hydrogen bond acceptor | 53 |
Hydrogen bond donor | 54 |
XlogP | -17.7 |
Synonyms | N/A |
Inchi Key | FTEBEHTUXBXWJY-HBXFPQPYSA-N |
Inchi ID | InChI=1S/C155H248N46O46/c1-17-79(12)122(150(243)192-101(59-76(6)7)139(232)188-105(64-113(161)209)128(221)172-70-117(213)176-98(153(246)247)36-23-27-53-158)199-147(240)111(72-203)196-142(235)107(66-115(163)211)189-138(231)100(58-75(4)5)185-140(233)102(61-85-39-43-88(206)44-40-85)186-133(226)92-35-24-28-54-169-116(212)50-48-97(129(222)174-80(13)125(218)197-120(77(8)9)148(241)182-93(131(224)178-92)34-22-26-52-157)181-135(228)96(47-49-112(160)208)180-130(223)91(33-21-25-51-156)177-132(225)94(37-29-55-170-154(164)165)179-137(230)99(57-74(2)3)184-134(227)95(38-30-56-171-155(166)167)183-151(244)123(82(15)204)200-144(237)103(62-86-41-45-89(207)46-42-86)187-141(234)106(65-114(162)210)190-143(236)109(68-119(216)217)194-152(245)124(83(16)205)201-145(238)104(60-84-31-19-18-20-32-84)193-149(242)121(78(10)11)198-126(219)81(14)175-136(229)108(67-118(214)215)191-146(239)110(71-202)195-127(220)90(159)63-87-69-168-73-173-87/h18-20,31-32,39-46,69,73-83,90-111,120-124,202-207H,17,21-30,33-38,47-68,70-72,156-159H2,1-16H3,(H2,160,208)(H2,161,209)(H2,162,210)(H2,163,211)(H,168,173)(H,169,212)(H,172,221)(H,174,222)(H,175,229)(H,176,213)(H,177,225)(H,178,224)(H,179,230)(H,180,223)(H,181,228)(H,182,241)(H,183,244)(H,184,227)(H,185,233)(H,186,226)(H,187,234)(H,188,232)(H,189,231)(H,190,236)(H,191,239)(H,192,243)(H,193,242)(H,194,245)(H,195,220)(H,196,235)(H,197,218)(H,198,219)(H,199,240)(H,200,237)(H,201,238)(H,214,215)(H,216,217)(H,246,247)(H4,164,165,170)(H4,166,167,171)/t79-,80-,81-,82+,83+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-,124-/m0/s1 |
PubChem CID | 76313784 |
ChEMBL | CHEMBL3102924 |
IUPHAR | N/A |
BindingDB | 50445107 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 0.1 nM | PMID24900623 | ChEMBL |
EC50 | 0.1 nM | PMID24900623 | BindingDB |
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