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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Motilin receptor
Species	Homo sapiens (Human)
Gene	MLNR
Synonym	GPR38 G protein-coupled receptor 38 G-protein coupled receptor 38 MTLR1 MTLR motilin receptor MOT-R [ Show all ]
Disease	Gastrointestinal disorders; Gastroesophageal reflux disease Irritable bowel syndrome Gastrointestinal disease Gastroesophageal reflux disease Gastric motility disorder Pain Dyspepsia Diarrhea Delayed gastric emptying; Gastroparesis Constipation Gastroparesis [ Show all ]
Length	412
Amino acid sequence	MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
UniProt	O43193
Protein Data Bank	N/A
GPCR-HGmod model	O43193
3D structure model	This predicted structure model is from GPCR-EXP O43193.
BioLiP	N/A
Therapeutic Target Database	T62306
ChEMBL	CHEMBL2203
IUPHAR	297
DrugBank	BE0003521

Ligand

Name	CHEMBL1078807
Molecular formula	C27H32N2O2S
IUPAC name	N-(3-benzyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-butylbenzenesulfonamide
Molecular weight	448.625
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	6.2
Synonyms	BDBM50415691
Inchi Key	FWROZMQRBMGKLZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H32N2O2S/c1-2-3-7-22-10-14-27(15-11-22)32(30,31)28-26-13-12-24-16-18-29(19-17-25(24)20-26)21-23-8-5-4-6-9-23/h4-6,8-15,20,28H,2-3,7,16-19,21H2,1H3
PubChem CID	46882348
ChEMBL	CHEMBL1078807
IUPHAR	N/A
BindingDB	50415691
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<3162.28 nM	PMID19804969	BindingDB,ChEMBL

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