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| Name | Muscarinic acetylcholine receptor M1 |
|---|---|
| Species | Rattus norvegicus (Rat) |
| Gene | Chrm1 |
| Synonym | cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor [ Show all ] |
| Disease | N/A for non-human GPCRs |
| Length | 460 |
| Amino acid sequence | MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC |
| UniProt | P08482 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | N/A |
| 3D structure model | No available structures or models |
| BioLiP | N/A |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL276 |
| IUPHAR | 13 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 10 |  DAPH | C20H15N3O2 | 329.359 | 4 / 3 | 3.8 | Yes |
| 12 |  CHEMBL68482 | C15H25N3OS | 295.445 | 5 / 0 | 3.7 | Yes |
| 716 |  CHEMBL308803 | C13H19N3O5S | 329.371 | 9 / 2 | N/A | N/A |
| 1082 |  CHEMBL115710 | C28H36F2N2O3 | 486.604 | 7 / 0 | 4.2 | Yes |
| 1215 |  CHEMBL339175 | C10H16N4 | 192.266 | 3 / 1 | 0.9 | Yes |
| 1330 |  CHEMBL68292 | C29H40N6O3 | 520.678 | 6 / 2 | 2.5 | No |
| 1415 |  1-(4-methylpiperazin-1-yl)-4-phenylphthalazine | C19H20N4 | 304.397 | 4 / 0 | 3.0 | Yes |
| 1971 |  Rutaecarpine | C18H13N3O | 287.322 | 2 / 1 | 3.0 | Yes |
| 2982 |  CHEMBL553066 | C17H23ClN2O3 | 338.832 | 4 / 3 | N/A | N/A |
| 3061 |  CHEMBL1773104 | C30H29N5O5S | 571.652 | 8 / 1 | 4.1 | No |
| 3095 |  PROPYLBENZILYLCHOLINE MUSTARD | C21H26ClNO3 | 375.893 | 4 / 1 | 4.2 | Yes |
| 3226 |  Lopac-D-2763 | C34H41N5O8S | 679.789 | 9 / 4 | N/A | No |
| 557377 |  SCHEMBL18211801 | C27H26FN3O3 | 459.521 | 5 / 2 | 3.8 | Yes |
| 3394 |  CHEMBL1916222 | C22H31N3O3 | 385.508 | 4 / 0 | 2.7 | Yes |
| 3591 |  tranylcypromine | C9H11N | 133.194 | 1 / 1 | 1.5 | Yes |
| 3684 |  CHEMBL1202000 | C64H77N13O6 | 1124.41 | 13 / 4 | 7.7 | No |
| 3749 |  Sodium valproate | C8H15NaO2 | 166.196 | 2 / 0 | N/A | N/A |
| 4570 |  CHEMBL131587 | C16H25N3S | 291.457 | 4 / 0 | 3.2 | Yes |
| 4680 |  CHEMBL356373 | C17H24N4 | 284.407 | 4 / 1 | 3.1 | Yes |
| 4735 |  1077-27-6 | C8H14O2S2 | 206.318 | 4 / 1 | 1.7 | Yes |
| 4762 |  CHEMBL48366 | C14H13ClN2 | 244.722 | 2 / 0 | 3.1 | Yes |
| 4961 |  CHEMBL103189 | C23H26N4OS | 406.548 | 4 / 1 | 2.4 | Yes |
| 5585 |  CHEMBL112528 | C28H29F2N3O2 | 477.556 | 6 / 1 | 4.6 | Yes |
| 5794 |  CHEMBL292103 | C11H19NO2S | 229.338 | 4 / 1 | 1.5 | Yes |
| 6214 |  N-(2-aminoethyl)-4-chlorobenzamide | C9H11ClN2O | 198.65 | 2 / 2 | 0.7 | Yes |
| 6383 |  CHEMBL302604 | C24H31N7O3 | 465.558 | 7 / 3 | -1.2 | Yes |
| 6412 |  CHEMBL68827 | C21H27N7O4S | 473.552 | 9 / 3 | -1.9 | Yes |
| 6589 |  CHEMBL442369 | C12H17N3O5S | 315.344 | 9 / 2 | N/A | N/A |
| 6607 |  carbachol | C6H15ClN2O2 | 182.648 | 3 / 1 | N/A | N/A |
| 6738 |  MRS 1754 | C26H26N6O4 | 486.532 | 6 / 2 | 4.9 | Yes |
| 6975 |  CHEMBL64067 | C20H21NO3 | 323.392 | 4 / 1 | 1.5 | Yes |
| 7035 |  NCGC00015331-01 | C34H48N4+2 | 512.786 | 2 / 2 | 9.5 | No |
| 7107 |  Tocris-0591 | C38H42N4O6 | 650.776 | 10 / 4 | 4.0 | No |
| 7135 |  CHEMBL446925 | C17H21Cl2N3OS | 386.335 | 3 / 1 | 2.7 | Yes |
| 7214 |  CHEMBL117193 | C16H25N3O | 275.396 | 4 / 1 | 2.6 | Yes |
| 7427 |  CHEMBL324518 | C29H32F2N2O | 462.585 | 5 / 1 | 5.7 | No |
| 7602 |  Carbetapentane citrate | C26H39NO10 | 525.595 | 11 / 4 | N/A | No |
| 7632 |  CHEMBL3298591 | C17H19N3O2S | 329.418 | 5 / 1 | 3.1 | Yes |
| 7719 |  beta-Narcotine | C22H23NO7 | 413.426 | 8 / 0 | 2.7 | Yes |
| 7940 |  CHEMBL214923 | C23H25F2NO3 | 401.454 | 6 / 1 | 4.1 | Yes |
| 8154 |  CHEMBL70154 | C30H42N6O3 | 534.705 | 6 / 2 | 3.0 | No |
| 8194 |  NCGC00015135-01 | C16H18N2OS | 286.393 | 3 / 2 | 3.0 | Yes |
| 8368 |  CHEMBL63746 | C25H25NO7S | 483.535 | 9 / 3 | N/A | N/A |
| 8474 |  CHEMBL543375 | C7H13ClN2O2 | 192.643 | 3 / 2 | N/A | N/A |
| 8479 |  CHEMBL126735 | C23H30N2 | 334.507 | 2 / 1 | 4.7 | Yes |
| 8547 |  Lopac-D-149 | C16H21NO3 | 275.348 | 4 / 0 | 0.0 | Yes |
| 8616 |  CHEMBL353276 | C22H24N4O | 360.461 | 5 / 1 | 3.5 | Yes |
| 8618 |  NEOSTIGMINE | C12H19N2O2+ | 223.296 | 2 / 0 | 1.5 | Yes |
| 8681 |  CHEMBL540013 | C26H33NO2 | 391.555 | 3 / 0 | 5.8 | No |
| 8710 |  CHEMBL545342 | C23H27Cl2NO | 404.375 | 2 / 1 | N/A | N/A |
| 8917 |  CHEMBL42553 | C16H19Cl2NO2 | 328.233 | 3 / 0 | 3.9 | Yes |
| 8971 |  CHEMBL158311 | C34H40N8O2S2 | 656.868 | 8 / 3 | 5.3 | No |
| 10435 |  SB 204070 hydrochloride | C19H27ClN2O4 | 382.885 | 6 / 1 | 3.5 | Yes |
| 10677 |  CHEMBL2021360 | C8H15NOS | 173.274 | 3 / 0 | 1.1 | Yes |
| 11253 |  cystamine | C4H12N2S2 | 152.274 | 4 / 2 | -1.0 | Yes |
| 11319 |  Lopac-N-1771 | C40H43N3O6 | 661.799 | 8 / 5 | 3.2 | No |
| 11708 |  DEXPROPRANOLOL | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
| 11795 |  cimetidine | C10H16N6S | 252.34 | 4 / 3 | 0.4 | Yes |
| 12078 |  Lopac-G-120 | C17H17N3O2 | 295.342 | 5 / 2 | 3.3 | Yes |
| 12282 |  CHEMBL540013 | C26H34ClNO2 | 428.013 | 3 / 1 | N/A | N/A |
| 12408 |  CHEMBL304042 | C21H23NO3 | 337.419 | 4 / 1 | 1.9 | Yes |
| 12410 |  CHEMBL294345 | C21H23NO3 | 337.419 | 4 / 1 | 1.9 | Yes |
| 464431 |  CHEMBL3608417 | C24H24FN5O3 | 449.486 | 6 / 2 | 1.4 | Yes |
| 12969 |  (S)-2-Amino-3-chloropropanoic acid | C3H6ClNO2 | 123.536 | 3 / 2 | -2.8 | Yes |
| 13068 |  BW 284c51 | C27H38N2O+2 | 406.614 | 1 / 0 | 5.2 | No |
| 13324 |  QUISQUALIC ACID | C5H7N3O5 | 189.127 | 6 / 3 | -3.9 | Yes |
| 13577 |  CHEMBL11497 | C29H30F3NO | 465.56 | 5 / 0 | 7.1 | No |
| 13640 |  CHEMBL26998 | C16H25NO | 247.382 | 2 / 1 | 4.1 | Yes |
| 13863 |  daphnetin | C9H6O4 | 178.143 | 4 / 2 | 1.2 | Yes |
| 13960 |  spermidine | C7H19N3 | 145.25 | 3 / 3 | -1.0 | Yes |
| 14121 |  CHEMBL466851 | C15H8BrCl2NO2 | 385.038 | 2 / 0 | 4.3 | Yes |
| 14230 |  180083-23-2 | C32H32N4O3 | 520.633 | 6 / 0 | 5.6 | No |
| 14781 |  CHEMBL443334 | C16H12FNO3 | 285.274 | 4 / 0 | 2.5 | Yes |
| 14910 |  NCGC00016051-01 | C13H8N4O3 | 268.232 | 7 / 4 | 0.2 | Yes |
| 14917 |  Lopac-P-8887 | C21H34O2 | 318.501 | 2 / 1 | 4.9 | Yes |
| 15014 |  Lopac-E-2375 | C29H40N2O4 | 480.649 | 6 / 1 | 4.7 | Yes |
| 15106 |  disulfiram | C10H20N2S4 | 296.524 | 4 / 0 | 3.9 | Yes |
| 15228 |  CHEMBL355350 | C19H26N4O | 326.444 | 5 / 1 | 3.2 | Yes |
| 15290 |  NCGC00015922-01 | C15H16N4O | 268.32 | 3 / 2 | 1.6 | Yes |
| 15419 |  CHEMBL540310 | C15H19ClN4 | 290.795 | 4 / 1 | N/A | N/A |
| 15754 |  hydroxylamine | H3NO | 33.03 | 2 / 2 | -1.2 | Yes |
| 15935 |  MLS000536463 | C23H23ClN2O6 | 458.895 | 6 / 1 | 5.3 | No |
| 16048 |  CHEMBL596509 | C21H12F4N2O3 | 416.332 | 8 / 0 | 4.6 | Yes |
| 16680 |  NCGC00016004-01 | C8H9N3O2 | 179.179 | 3 / 1 | -0.1 | Yes |
| 16827 |  CHEMBL168581 | C16H25NOS | 279.442 | 3 / 0 | 4.1 | Yes |
| 17056 |  CHEMBL321842 | C11H18N2O | 194.278 | 3 / 0 | 1.2 | Yes |
| 17383 |  CHEMBL1773096 | C21H18FN3O4S | 427.45 | 6 / 1 | 3.6 | Yes |
| 17512 |  CHEMBL68160 | C15H25N3OS | 295.445 | 5 / 0 | 3.7 | Yes |
| 17718 |  CHEMBL504572 | C16H8F5NO3 | 357.236 | 8 / 0 | 3.8 | Yes |
| 17889 |  Bmy-7378 | C22H31N3O3 | 385.508 | 5 / 0 | 2.8 | Yes |
| 18523 |  CHEMBL126332 | C15H25N3O2S | 311.444 | 6 / 0 | 3.9 | Yes |
| 18640 |  NCGC00017128-01 | C16H16N5NaO7S2 | 477.442 | 12 / 2 | N/A | No |
| 18813 |  tcpobop | C16H8Cl4N2O2 | 402.052 | 4 / 0 | 6.0 | No |
| 18899 |  AC1LQZR1 | C27H30N4O | 426.564 | 3 / 1 | 5.4 | No |
| 19182 |  Tocris-0871 | C5H10N2S | 130.209 | 2 / 1 | 0.6 | Yes |
| 19396 |  Lopac-A-8598 | C9H11N3O4 | 225.204 | 5 / 3 | -2.4 | Yes |
| 19461 |  CHEMBL76107 | C14H23N3OS | 281.418 | 5 / 0 | 3.0 | Yes |
| 19559 |  CHEMBL217456 | C27H33F2NO3 | 457.562 | 6 / 0 | 5.8 | No |
| 19742 |  CHEMBL2112509 | C24H27F2NO3 | 415.481 | 6 / 0 | 4.5 | Yes |
| 20167 |  imipramine | C19H24N2 | 280.415 | 2 / 0 | 4.8 | Yes |
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